ATXN1L and ZSWIM8

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)

		ATXN1L	ZSWIM8
Description		ataxin 1 like	zinc finger SWIM-type containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite Cell Projection	Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding POZ Domain Binding	Zinc Ion Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Type I Interferon-mediated Signaling Pathway Target-directed MiRNA Degradation Positive Regulation Of MiRNA Catabolic Process
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908)
Interacting Genes		83 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SPMIP9 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8	5 interacting genes: ATN1 ATXN1 ATXN1L CTDSP1 PRMT2
Entrez ID		342371	23053
HPRD ID		19555	17199
Ensembl ID		ENSG00000224470	ENSG00000214655
Uniprot IDs		P0C7T5	A7E2V4 S4R410
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Androgen Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Androgen Receptor Signaling Pathway Axolemma Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Clathrin Adaptor Activity Regulation Of Protein Localization To Cell Periphery Transcription Corepressor Activity Clathrin Coat Assembly Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Body Positive Regulation Of Response To Oxidative Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Component Of Presynaptic Endocytic Zone Membrane Double-stranded Methylated DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Protein Localization Clathrin-coated Pit Clathrin-dependent Endocytosis Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization Chromatin Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process	POZ Domain Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Social Behavior Lung Alveolus Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Histone H3R8 Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Memory Nuclear Matrix Nuclear Progesterone Receptor Binding Nucleoplasm Regulation Of G1/S Transition Of Mitotic Cell Cycle Learning Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleolus Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Brain Development RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Macromolecule Metabolic Process Protein-arginine N-methyltransferase Activity Negative Regulation Of Cell Cycle Process Poly(G) Binding Learning Or Memory Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Proliferation Transcription Coactivator Activity Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Peroxisome Proliferator Activated Receptor Binding Regulation Of Macromolecule Metabolic Process Cognition Nuclear Inclusion Body Regulation Of Mitotic Cell Cycle Phase Transition
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