ATXN1L and DAB2

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)

		ATXN1L	DAB2
Gene Name		ataxin 1-like	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Dendrite	Nucleolus Lysosomal Membrane Plasma Membrane Coated Pit Focal Adhesion Apical Plasma Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Transforming Growth Factor Beta Receptor Homodimeric Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding RNA Binding Protein Binding	Integrin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Extracellular Matrix Organization Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Cell Morphogenesis Involved In Differentiation In Utero Embryonic Development Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Pinocytosis Apoptotic Process Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Endoderm Development Excretion Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Clathrin Coat Assembly Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Formation of annular gap junctions Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Pancreatic cancer ( 22158540) Urate levels ( 23263486)
Protein-Protein Interactions		57 interactors: ACO2 ACOT7 ADORA1 AFAP1L2 ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ATXN1 CAMSAP2 CBFA2T2 CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FUS GAS7 GMEB2 GORASP2 GPATCH8 H2AFY HGS HIVEP1 HSFX1 MATN2 MBD1 MBD6 MEOX2 METTL17 NBR1 NCOR1 NCOR2 NIT1 PHPT1 PICK1 PRRC2B RAD54L2 RBFOX2 RRAGC SCAF11 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 THY1 TMEM25 TMEM8B TRIP11 YY1AP1 ZC3H7B ZSWIM8	37 interactors: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 DYT10 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SMAD2 SMAD3 SMURF2 SRC TGFBR1 TGFBR2
Entrez ID		342371	1601
HPRD ID		19555	03139
Ensembl ID		ENSG00000224470	ENSG00000153071
Uniprot IDs		P0C7T5	B2RAW0 P98082
PDB IDs			2LSW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Histone Deacetylation Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Protein Deacetylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Histone Deacetylation Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signaling Regulation Of Histone Modification Regulation Of Protein Deacetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Cellular Response To Starvation Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Neuron Differentiation Positive Regulation Of Histone Modification Cellular Response To Nutrient Levels Response To Starvation Nervous System Development White Fat Cell Differentiation Chromatin Organization Neuron Development Negative Regulation Of Protein Localization To Plasma Membrane RNA Splicing Regulation Of Chromosome Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway	Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Signal Transduction Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signal Transduction Signaling Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Developmental Process Positive Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Anatomical Structure Morphogenesis Multicellular Organismal Development Wound Healing Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Nervous System Development Embryonic Morphogenesis System Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune System Process Anatomical Structure Development Platelet Activation
Tagcloud ?		ataxia ataxin autism candidates continuously counterparts discovery encoded enriched hematologic hematopoietic heretofore hsc hscs interactomes modules networks null observing offering progeny quickly quiescence quiescent regenerated replenish representation similarity unappreciated	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		ataxia ataxin autism candidates continuously counterparts discovery encoded enriched hematologic hematopoietic heretofore hsc hscs interactomes modules networks null observing offering progeny quickly quiescence quiescent regenerated replenish representation similarity unappreciated	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?