ATXN1L and AP1G2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)

		ATXN1L	AP1G2
Description		ataxin 1 like	adaptor related protein complex 1 subunit gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite Cell Projection	Golgi Membrane Endosome Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Membrane Membrane Coat AP-1 Adaptor Complex Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Synapse Intracellular Vesicle
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding POZ Domain Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Vesicle-mediated Transport
Pathways			Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Blood protein levels ( 30072576) Sudden cardiac arrest ( 21658281)
Interacting Genes		83 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SPMIP9 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8	13 interacting genes: AFTPH AP1S1 AP1S2 ATXN1L CENPK DANCR KDM1A NEDD4 PRMT6 RABEP1 SNCA SYNRG XRN1
Entrez ID		342371	8906
HPRD ID		19555	04638
Ensembl ID		ENSG00000224470	ENSG00000213983
Uniprot IDs		P0C7T5	O75843 Q86U03 Q86V28
PDB IDs			2E9G 2YMT 3ZHF 4BCX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Androgen Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Androgen Receptor Signaling Pathway Axolemma Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Clathrin Adaptor Activity Regulation Of Protein Localization To Cell Periphery Transcription Corepressor Activity Clathrin Coat Assembly Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Body Positive Regulation Of Response To Oxidative Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Component Of Presynaptic Endocytic Zone Membrane Double-stranded Methylated DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Protein Localization Clathrin-coated Pit Clathrin-dependent Endocytosis Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization Chromatin Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process	AP-1 Adaptor Complex Endocytosis Clathrin Adaptor Activity Trans-Golgi Network Membrane Protein Transport Import Into Cell Melanosome Assembly Vesicle-mediated Transport Platelet Dense Granule Organization Establishment Of Protein Localization Membrane Coat Cytoplasmic Vesicle Receptor-mediated Endocytosis Cytoplasmic Vesicle Membrane Cellular Localization Terminal Bouton Melanosome Organization Establishment Of Localization In Cell Intracellular Protein Transport Pigment Granule Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Negative Regulation Of Transcription By RNA Polymerase II Formation Of Structure Involved In A Symbiotic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Stem Cell Proliferation Cellular Response To Puromycin Cellular Response To Cycloheximide Histone H2AR3 Methyltransferase Activity Intracellular Protein Localization Secretory Granule Organization Intracellular Transport Clathrin-coated Pit Receptor Internalization Channel Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Clathrin-coated Vesicle Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Early Endosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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