ATXN1L and AFAP1L2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)

		ATXN1L	AFAP1L2
Description		ataxin 1 like	actin filament associated protein 1 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite Cell Projection	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding POZ Domain Binding	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Systolic blood pressure ( 29212154)
Interacting Genes		83 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SPMIP9 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8	10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2
Entrez ID		342371	84632
HPRD ID		19555	13902
Ensembl ID		ENSG00000224470	ENSG00000169129
Uniprot IDs		P0C7T5	A0A8Q3SIY9 B7Z2Q0 Q8N4X5
PDB IDs			2COF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Androgen Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Androgen Receptor Signaling Pathway Axolemma Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Clathrin Adaptor Activity Regulation Of Protein Localization To Cell Periphery Transcription Corepressor Activity Clathrin Coat Assembly Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Body Positive Regulation Of Response To Oxidative Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Component Of Presynaptic Endocytic Zone Membrane Double-stranded Methylated DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Protein Localization Clathrin-coated Pit Clathrin-dependent Endocytosis Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization Chromatin Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process	Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Telomere Assembly RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Telomere Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization DNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Telomerase Positive Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Cellular Component Organization Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Chromosome Organization Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Protection From Non-homologous End Joining At Telomere Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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