ATXN1L and UNKL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATXN1L	UNKL
Description		ataxin 1 like	unk like zinc finger
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite Cell Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding POZ Domain Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Protein Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Refractive error ( 32231278) Serum immune biomarker levels ( 32066700)
Interacting Genes		83 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SPMIP9 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8	42 interacting genes: APOBEC3C ATXN1L BAG3 BAG4 CABP2 CARD9 CPSF2 CPSF7 CREB5 CRYBA2 CTBP1 DDX50 DMRTB1 EXOSC7 EXOSC8 FBLN1 FRS3 HNRNPF HOOK1 HOXA1 KCTD9 KDM1A KRT31 LMO1 MGAT5B NID2 NTAQ1 POLR1C PPP1R16A QKI RAB26 RAC1 RBPMS RNF10 RPS28 SAXO4 SMARCD2 SRPK2 TFIP11 TGM7 TRIM55 TRIM63
Entrez ID		342371	64718
HPRD ID		19555	15612
Ensembl ID		ENSG00000224470	ENSG00000059145
Uniprot IDs		P0C7T5	A0A0A0MRZ1 E9PDK2 Q9H9P5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Androgen Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Androgen Receptor Signaling Pathway Axolemma Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Clathrin Adaptor Activity Regulation Of Protein Localization To Cell Periphery Transcription Corepressor Activity Clathrin Coat Assembly Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Body Positive Regulation Of Response To Oxidative Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Component Of Presynaptic Endocytic Zone Membrane Double-stranded Methylated DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Protein Localization Clathrin-coated Pit Clathrin-dependent Endocytosis Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization Chromatin Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process	RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA Processing Transcription Coactivator Activity Nucleus RNA Metabolic Process MRNA Metabolic Process Negative Regulation Of Protein Targeting To Mitochondrion RNA 3'-end Processing Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Negative Regulation Of Establishment Of Protein Localization To Mitochondrion U4 SnRNA 3'-end Processing Identical Protein Binding RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) TRNA Decay Nuclear MRNA Surveillance Ruffle Assembly Protein Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Adenyl-nucleotide Exchange Factor Activity MRNA Processing RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) MRNA Cleavage And Polyadenylation Specificity Factor Complex Macromolecule Metabolic Process Positive Regulation Of Myelination Regulation Of RNA Splicing
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