NMT2 and PRKCZ

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NMT2	PRKCZ
Gene Name		N-myristoyltransferase 2	protein kinase C, zeta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extrinsic Component Of Membrane	Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Filamentous Actin Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Glycylpeptide N-tetradecanoyltransferase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Phospholipase Binding Insulin Receptor Substrate Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Phototransduction, Visible Light Viral Process Rhodopsin Mediated Signaling Pathway N-terminal Peptidyl-glycine N-myristoylation Virion Assembly Viral Protein Processing Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Transport Of Virus	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Long-term Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Platelet Activation Negative Regulation Of Protein Complex Assembly Actin Cytoskeleton Reorganization Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-4 Production Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Negative Regulation Of Hydrolase Activity Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-10 Secretion
Pathways		Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins Inactivation, recovery and regulation of the phototransduction cascade HIV Life Cycle Visual phototransduction The phototransduction cascade HIV Infection Diseases associated with visual transduction Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF GPVI-mediated activation cascade Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Height ( 20881960) Reasoning ( 21107309)
Protein-Protein Interactions		12 interactors: ANXA4 ANXA7 APP BCL2 CASP3 CSNK2B PPP1CC PRKCZ SMN1 TK1 TMED9 TP53	84 interactors: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B HABP4 HIST1H1A HIST1H1B HIST3H3 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71
Entrez ID		9397	5590
HPRD ID		11948	01504
Ensembl ID			ENSG00000067606
Uniprot IDs		O60551 Q5VUC6	Q05513
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death Release Of Cytochrome C From Mitochondria Response To Light Stimulus Response To Radiation Glial Cell Apoptotic Process Apoptotic Mitochondrial Changes Response To Organic Substance B Cell Lineage Commitment Regulation Of Protein Phosphorylation Behavior Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Protein Metabolic Process Response To Wounding Developmental Process Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Response To UV Membrane Organization Regulation Of Phosphorus Metabolic Process Nervous System Development Response To Oxidative Stress Cell Growth Transforming Growth Factor Beta Receptor Signaling Pathway Hemostasis Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Generation Of Neurons Cell Differentiation Negative Regulation Of Programmed Cell Death T Cell Lineage Commitment Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Cell Death Cellular Response To Glucose Starvation Neurogenesis Growth Photoperiodism Entrainment Of Circadian Clock Regulation Of Cellular Ketone Metabolic Process Response To Toxic Substance Tissue Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Defense Response Fc Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Fc-epsilon Receptor Signaling Pathway Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Apoptotic Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Death Apoptotic Process Response To Fibroblast Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		125b aberrantly augmentation cadherin causal cbx7 chromobox codysregulated dcis dok4 dysregulation egr1 epithelium hn mammoplasty mcf7 memo1 microdissection mirna neoplasias nfib noncoding nrip1 paired pairs preinvasive rip140 rm underexpressed	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Difference) ?		125b aberrantly augmentation cadherin causal cbx7 chromobox codysregulated dcis dok4 dysregulation egr1 epithelium hn mammoplasty mcf7 memo1 microdissection mirna neoplasias nfib noncoding nrip1 paired pairs preinvasive rip140 rm underexpressed	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Intersection) ?