NRXN2 and MACF1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NRXN2	MACF1
Description		neurexin 2	microtubule actin crosslinking factor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Cell Leading Edge Ruffle Membrane Cell Projection
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Cadherin Binding Metal Ion Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Assembly	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Projection Organization Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Multicellular Organismal Process Regulation Of Focal Adhesion Assembly Establishment Of Protein Localization To Membrane Regulation Of Neuron Projection Arborization
Pathways		Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 29273807) Gout ( 33832965) Lymphocyte count ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Serum uric acid levels ( 29403010 30993211) Urate levels ( 21768215 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500)	Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 20686565 25961943) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 27189021 28869590 29358691 32499647 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Ventral thalamic nuclei volume ( 34006833)
Interacting Genes		9 interacting genes: AFDN CASK DDX24 MACF1 MAPK6 NLGN1 NLGN2 NLGN3 PATJ	38 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DSCAM DSCR9 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN LCOR MAPK9 MAPRE1 MTNR1B NRCAM NRIP1 NRXN1 NRXN2 PCNT PKNOX1 PLXND1 PRKCD RIPK4 SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC USP7
Entrez ID		9379	23499
HPRD ID		11859	09750
Ensembl ID		ENSG00000110076	ENSG00000127603
Uniprot IDs		A0A8I5KY42 P58401 Q9P2S2	H3BPE1 O94854 Q6ZSD7 Q9UPN3
PDB IDs		4NXR	4Z6G 5VE9 5X57
Enriched GO Terms of Interacting Partners?		Neurexin Family Protein Binding Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization Presynapse Assembly Neuron Cell-cell Adhesion Cell Junction Assembly Cell Adhesion Molecule Binding Presynapse Organization Excitatory Synapse Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Dendritic Spine Development Asymmetric, Glutamatergic, Excitatory Synapse Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Development Terminal Button Organization Membrane Assembly Positive Regulation Of Synapse Assembly Postsynaptic Density Protein 95 Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Synapse Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Cell Junction Assembly Regulation Of Respiratory System Process Regulation Of Nervous System Process Positive Regulation Of Synaptic Transmission, GABAergic Cell Adhesion Positive Regulation Of Synaptic Transmission Regulation Of Nervous System Development Regulation Of Respiratory Gaseous Exchange Regulation Of Synapse Assembly Cell-cell Adhesion Modulation Of Chemical Synaptic Transmission Cell-cell Junction Organization Localization Within Membrane Postsynaptic Specialization Membrane Cell Junction Regulation Of Synaptic Transmission, GABAergic Tight Junction Postsynaptic Membrane Synapse Organization Positive Regulation Of Developmental Process	Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Positive Regulation Of Cellular Component Organization Vocal Learning Positive Regulation Of Axonogenesis Observational Learning Positive Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Synapse Assembly Neuron Recognition Auditory Behavior Mechanosensory Behavior Social Behavior Vocalization Behavior Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Regulation Of Axonogenesis Cell Junction Assembly Neuron Projection Morphogenesis Positive Regulation Of Nervous System Development Regulation Of Axon Extension Glutamatergic Synapse Negative Regulation Of Filopodium Assembly Cell Projection Morphogenesis Anatomical Structure Morphogenesis Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Family Protein Binding Angiogenesis Postsynaptic Density Protein 95 Clustering Neuron Projection Development Positive Regulation Of Axon Extension Modulation Of Chemical Synaptic Transmission Neurotransmitter Secretion Postsynaptic Membrane Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Neurogenesis Regulation Of Filopodium Assembly Regulation Of Cell Projection Assembly Synapse Cell Recognition Postsynaptic Membrane Organization Axon Synapse Organization Presynaptic Membrane Positive Regulation Of Intracellular Transport Neuronal Ion Channel Clustering Regulation Of Postsynapse Organization Cilium Assembly
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