NRXN2 and NLGN2

Number of citations of the paper that reports this interaction (PubMedID 8576240)
0

Data Source:
BioGRID (pull down)

		NRXN2	NLGN2
Description		neurexin 2	neuroligin 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse	Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Dendritic Shaft Synapse Postsynaptic Membrane Excitatory Synapse Inhibitory Synapse Ribbon Synapse Glycinergic Synapse Dopaminergic Synapse GABA-ergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Postsynaptic Specialization Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Assembly	Thigmotaxis Regulation Of Respiratory Gaseous Exchange By Nervous System Process Cell Adhesion Neuron Cell-cell Adhesion Synapse Assembly Jump Response Positive Regulation Of Cell Population Proliferation Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Cell Surface Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Synaptic Transmission, GABAergic Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Neurotransmitter-gated Ion Channel Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Postsynaptic Specialization Assembly Presynapse Assembly Insulin Metabolic Process Positive Regulation Of Protein Localization To Synapse Positive Regulation Of T-SNARE Clustering Inhibitory Synapse Assembly Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 29273807) Gout ( 33832965) Lymphocyte count ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Serum uric acid levels ( 29403010 30993211) Urate levels ( 21768215 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500)	Refractive error ( 32231278) Uterine fibroids ( 30194396) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: AFDN CASK DDX24 MACF1 MAPK6 NLGN1 NLGN2 NLGN3 PATJ	8 interacting genes: DLG2 DLG3 DLG4 MDGA1 NRXN1 NRXN2 NRXN3 PATJ
Entrez ID		9379	57555
HPRD ID		11859	07348
Ensembl ID		ENSG00000110076	ENSG00000169992
Uniprot IDs		A0A8I5KY42 P58401 Q9P2S2	Q8NFZ4
PDB IDs		4NXR	5XEQ 8GS4
Enriched GO Terms of Interacting Partners?		Neurexin Family Protein Binding Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization Presynapse Assembly Neuron Cell-cell Adhesion Cell Junction Assembly Cell Adhesion Molecule Binding Presynapse Organization Excitatory Synapse Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Dendritic Spine Development Asymmetric, Glutamatergic, Excitatory Synapse Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Development Terminal Button Organization Membrane Assembly Positive Regulation Of Synapse Assembly Postsynaptic Density Protein 95 Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Synapse Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Cell Junction Assembly Regulation Of Respiratory System Process Regulation Of Nervous System Process Positive Regulation Of Synaptic Transmission, GABAergic Cell Adhesion Positive Regulation Of Synaptic Transmission Regulation Of Nervous System Development Regulation Of Respiratory Gaseous Exchange Regulation Of Synapse Assembly Cell-cell Adhesion Modulation Of Chemical Synaptic Transmission Cell-cell Junction Organization Localization Within Membrane Postsynaptic Specialization Membrane Cell Junction Regulation Of Synaptic Transmission, GABAergic Tight Junction Postsynaptic Membrane Synapse Organization Positive Regulation Of Developmental Process	Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Vocalization Behavior Protein Localization To Cell Junction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Social Behavior Cell-cell Adhesion Neuron Cell-cell Adhesion Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Trans-synaptic Signaling Ionotropic Glutamate Receptor Binding Synaptic Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Establishment Or Maintenance Of Cell Polarity Learning Cell Adhesion Gephyrin Clustering Involved In Postsynaptic Density Assembly Localization Within Membrane NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Nervous System Development Postsynaptic Membrane Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cell-cell Signaling Vocal Learning Cell Junction Assembly Signaling Learning Or Memory Postsynaptic Membrane Organization Observational Learning Cell Communication Cell Projection Cell Adhesion Molecule Binding Cognition Juxtaparanode Region Of Axon Synapse Assembly Kinase Binding Postsynaptic Density Membrane Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Mechanosensory Behavior Nervous System Process
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