NIT1 and ATXN1L

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)

		NIT1	ATXN1L
Description		nitrilase 1	ataxin 1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Nucleus Nucleoplasm Nucleolus Dendrite Cell Projection
	Molecular Function	Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Deaminated Glutathione Amidase Activity	DNA Binding Chromatin Binding RNA Binding Protein Binding POZ Domain Binding
	Biological Process	Amide Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		3 interacting genes: ATXN1L XRCC6 ZFYVE9	83 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SPMIP9 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8
Entrez ID		4817	342371
HPRD ID		07056	19555
Ensembl ID		ENSG00000158793	ENSG00000224470
Uniprot IDs		B7Z410 Q86X76	P0C7T5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor III Complex Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity DNA End Binding Cellular Hyperosmotic Salinity Response DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex POZ Domain Binding Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Hyperosmotic Salinity Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Nonhomologous End Joining Complex Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Positive Regulation Of Hematopoietic Stem Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Response To X-ray Cellular Response To Salt Stress Double-strand Break Repair Via Classical Nonhomologous End Joining Neutrophil Activation Involved In Immune Response Serotonin Transport IgG Binding Positive Regulation Of Inflammatory Response To Antigenic Stimulus 1-phosphatidylinositol Binding Plasma Membrane Protein Complex Positive Regulation Of Mast Cell Degranulation Activation Of Immune Response Myeloid Cell Apoptotic Process Regulation Of Acute Inflammatory Response To Antigenic Stimulus Endocytosis Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Defense Response Cellular Hyperosmotic Response Positive Regulation Of Protein Localization To Cell Surface Response To Salt Stress Negative Regulation Of Myeloid Cell Apoptotic Process	Negative Regulation Of Androgen Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Androgen Receptor Signaling Pathway Axolemma Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Clathrin Adaptor Activity Regulation Of Protein Localization To Cell Periphery Transcription Corepressor Activity Clathrin Coat Assembly Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Body Positive Regulation Of Response To Oxidative Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Component Of Presynaptic Endocytic Zone Membrane Double-stranded Methylated DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Protein Localization Clathrin-coated Pit Clathrin-dependent Endocytosis Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization Chromatin Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process
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