UBE4A and CASP6

Number of citations of the paper that reports this interaction (PubMedID 11802788)
29

Data Source:
BioGRID (enzymatic study)

		UBE4A	CASP6
Description		ubiquitination factor E4A	caspase 6
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ERAD Pathway	Activation Of Innate Immune Response Proteolysis Apoptotic Process Protein Autoprocessing Epithelial Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Protein Maturation Positive Regulation Of Necroptotic Process Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Staurosporine Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		16 interacting genes: CASP6 CLIC6 EPHA2 FILNC1 GZMB IP6K1 MAVS NFE2L1 PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	43 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 RNF31 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		9354	839
HPRD ID		06793	03321
Ensembl ID		ENSG00000110344	ENSG00000138794
Uniprot IDs		Q14139	P55212
PDB IDs		1WGM	2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV 8EG5 8EG6 8F78 8F96 8F97 8F98 8F99 8F9A 8F9B 8F9C 8F9D 8FBV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process ATP Binding Molecular Function Activator Activity Protein K6-linked Ubiquitination Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Pyroptotic Inflammatory Response Nucleotide Binding Notochord Cell Development Regulation Of Nucleus Organization Delta7-sterol 5(6)-desaturase Activity Protein K11-linked Ubiquitination Flavin Adenine Dinucleotide Catabolic Process D4 Dopamine Receptor Binding Positive Regulation Of IP-10 Production Negative Regulation Of Viral Genome Replication Response To Stress Axial Mesoderm Formation Regulation Of Establishment Of Protein Localization Cytolytic Granule Lumen C-5 Sterol Desaturase Activity Negative Regulation Of BMP Signaling Pathway VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination D3 Dopamine Receptor Binding Regulation Of Peroxisome Organization Negative Regulation Of Lymphangiogenesis Notochord Formation Alcohol Metabolic Process Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Macromolecule Catabolic Process Protein Autoubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity D2 Dopamine Receptor Binding	Regulation Of Programmed Cell Death Cytoplasm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleus Ripoptosome CD95 Death-inducing Signaling Complex Response To Stress Programmed Cell Death Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Death-inducing Signaling Complex Cytoskeleton Organization Ubiquitin Protein Ligase Binding Nuclear Matrix Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Modification Process Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Cytosol Regulation Of Protein Metabolic Process Intermediate Filament Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Macromolecule Metabolic Process Cellular Response To Stress Organelle Organization Structural Constituent Of Cytoskeleton Structural Constituent Of Nuclear Lamina Positive Regulation Of Metabolic Process Regulation Of Signaling Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cell Communication Response To Hypoxia Regulation Of Macroautophagy Positive Regulation Of DNA-binding Transcription Factor Activity Apolipoprotein Binding Death Receptor Binding Astrocyte Activation
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