UBE4A and RSAD2

Number of citations of the paper that reports this interaction (PubMedID 31812350)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		UBE4A	RSAD2
Description		ubiquitination factor E4A	radical S-adenosyl methionine domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Fibrillar Center Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Catalytic Activity Protein Binding Lyase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ERAD Pathway	Immune System Process Response To Virus Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Virus Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)	Severe autoimmune type 2 diabetes ( 34737425)
Interacting Genes		16 interacting genes: CASP6 CLIC6 EPHA2 FILNC1 GZMB IP6K1 MAVS NFE2L1 PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	6 interacting genes: APOC1 APOC2 APOC4 RHBDD2 TRAF6 UBE4A
Entrez ID		9354	91543
HPRD ID		06793	07423
Ensembl ID		ENSG00000110344	ENSG00000134321
Uniprot IDs		Q14139	C9J674 Q8WXG1
PDB IDs		1WGM
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process ATP Binding Molecular Function Activator Activity Protein K6-linked Ubiquitination Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Pyroptotic Inflammatory Response Nucleotide Binding Notochord Cell Development Regulation Of Nucleus Organization Delta7-sterol 5(6)-desaturase Activity Protein K11-linked Ubiquitination Flavin Adenine Dinucleotide Catabolic Process D4 Dopamine Receptor Binding Positive Regulation Of IP-10 Production Negative Regulation Of Viral Genome Replication Response To Stress Axial Mesoderm Formation Regulation Of Establishment Of Protein Localization Cytolytic Granule Lumen C-5 Sterol Desaturase Activity Negative Regulation Of BMP Signaling Pathway VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination D3 Dopamine Receptor Binding Regulation Of Peroxisome Organization Negative Regulation Of Lymphangiogenesis Notochord Formation Alcohol Metabolic Process Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Macromolecule Catabolic Process Protein Autoubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity D2 Dopamine Receptor Binding	High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Triglyceride Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Lipoprotein Particle Clearance Lipid Homeostasis Negative Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Clearance Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Metabolic Process Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Lipid Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Negative Regulation Of Endocytosis Sterol Transport Negative Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Homeostatic Process ERAD Pathway Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Metabolic Process Regulation Of Receptor-mediated Endocytosis Regulation Of Ketone Metabolic Process Protein Catabolic Process Regulation Of Lipid Transport Organophosphate Ester Transport Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Organic Hydroxy Compound Transport Chylomicron Remodeling
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