UBE4A and IP6K1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		UBE4A	IP6K1
Description		ubiquitination factor E4A	inositol hexakisphosphate kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Diphosphoinositol Pentakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ERAD Pathway	Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Organophosphate Biosynthetic Process Negative Regulation Of Cold-induced Thermogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of pyrophosphates in the cytosol Synthesis of IPs in the nucleus
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hand grip strength ( 29691431) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 29769521 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Ulcerative colitis ( 25082827) Visceral adipose tissue volume ( 34128465)
Interacting Genes		16 interacting genes: CASP6 CLIC6 EPHA2 FILNC1 GZMB IP6K1 MAVS NFE2L1 PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	12 interacting genes: ADAMTSL4 CACNA1A CLK1 COPS2 DDB1 EXOSC7 GPS1 PICK1 RAB3IL1 RPL11 UBE4A VIM
Entrez ID		9354	9807
HPRD ID		06793	07379
Ensembl ID		ENSG00000110344	ENSG00000176095
Uniprot IDs		Q14139	Q92551
PDB IDs		1WGM
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process ATP Binding Molecular Function Activator Activity Protein K6-linked Ubiquitination Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Pyroptotic Inflammatory Response Nucleotide Binding Notochord Cell Development Regulation Of Nucleus Organization Delta7-sterol 5(6)-desaturase Activity Protein K11-linked Ubiquitination Flavin Adenine Dinucleotide Catabolic Process D4 Dopamine Receptor Binding Positive Regulation Of IP-10 Production Negative Regulation Of Viral Genome Replication Response To Stress Axial Mesoderm Formation Regulation Of Establishment Of Protein Localization Cytolytic Granule Lumen C-5 Sterol Desaturase Activity Negative Regulation Of BMP Signaling Pathway VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination D3 Dopamine Receptor Binding Regulation Of Peroxisome Organization Negative Regulation Of Lymphangiogenesis Notochord Formation Alcohol Metabolic Process Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Macromolecule Catabolic Process Protein Autoubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity D2 Dopamine Receptor Binding	Regulation Of Protein Neddylation Protein Deneddylation Protein Neddylation COP9 Signalosome
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