HP and RBBP6

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		HP	RBBP6
Description		haptoglobin	RB binding protein 6, ubiquitin ligase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Nucleus Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck Protein-containing Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Defense Response Acute-phase Response Inflammatory Response Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Multicellular Organism Growth Embryonic Organ Development Somite Development
Pathways		Scavenging of heme from plasma Neutrophil degranulation	RHOBTB1 GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Cholesterol, total ( 20686565 25961943) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 20686565 25961943) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	44 interacting genes: ACOT13 AGO2 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 CPSF3 EIF4ENIF1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TFIP11 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9
Entrez ID		3240	5930
HPRD ID		00772	02964
Ensembl ID		ENSG00000257017	ENSG00000122257
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	Q7Z6E9
PDB IDs		4WJG 4X0L 5HU6 6TB2 8XMP 8XMQ 8XMW 9FHB 9FMU	2C7H 2YSA 2YUR 3ZTG 6E5X
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Integrin AlphaM-beta2 Complex Protein Phosphatase Binding Positive Regulation Of Neutrophil Degranulation Extracellular Exosome Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neutrophil Degranulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Complement Component C3b Binding Regulation Of Immune Response Protein Kinase Binding Protein Stabilization Protein Metabolic Process Endocytic Vesicle Lumen Response To Other Organism Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Response To Stress Ficolin-1-rich Granule Lumen Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Leukocyte Activation Integrin Complex Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Microglial Cell Activation Regulation Of Superoxide Metabolic Process Phagocytosis, Engulfment Response To External Biotic Stimulus Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Defense Response Endodermal Cell Differentiation Receptor-mediated Endocytosis Response To Cocaine	Negative Regulation Of Developmental Process PML Body Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Differentiation SUMO Transferase Activity Regulation Of Cell Cycle Phase Transition Cellular Response To Actinomycin D Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Response To Actinomycin D Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Disordered Domain Specific Binding Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To UV-C Glial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Locomotion Positive Regulation Of Catabolic Process Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Antibiotic Regulation Of Cell Cycle G1/S Phase Transition Ubiquitin Protein Ligase Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Migration Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing
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