HP and ADAMTS4

Number of citations of the paper that reports this interaction (PubMedID 16099106)
0

Data Source:
HPRD (two hybrid)

		HP	ADAMTS4
Description		haptoglobin	ADAM metallopeptidase with thrombospondin type 1 motif 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Defense Response Acute-phase Response Inflammatory Response Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium
Pathways		Scavenging of heme from plasma Neutrophil degranulation	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Cholesterol, total ( 20686565 25961943) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 20686565 25961943) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 27182965 31361310 31619474) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 27863252 32888494)
Interacting Genes		21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		3240	9507
HPRD ID		00772	04853
Ensembl ID		ENSG00000257017	ENSG00000158859
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	O75173
PDB IDs		4WJG 4X0L 5HU6 6TB2 8XMP 8XMQ 8XMW 9FHB 9FMU	2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Integrin AlphaM-beta2 Complex Protein Phosphatase Binding Positive Regulation Of Neutrophil Degranulation Extracellular Exosome Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neutrophil Degranulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Complement Component C3b Binding Regulation Of Immune Response Protein Kinase Binding Protein Stabilization Protein Metabolic Process Endocytic Vesicle Lumen Response To Other Organism Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Response To Stress Ficolin-1-rich Granule Lumen Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Leukocyte Activation Integrin Complex Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Microglial Cell Activation Regulation Of Superoxide Metabolic Process Phagocytosis, Engulfment Response To External Biotic Stimulus Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Defense Response Endodermal Cell Differentiation Receptor-mediated Endocytosis Response To Cocaine	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing
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