HP and C1RL

Number of citations of the paper that reports this interaction (PMID 15385675)
9

Data Source:
HPRD (in vitro)

		HP	C1RL
Gene Name		haptoglobin	complement component 1, r subcomponent-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Catalytic Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Serine-type Endopeptidase Activity
	Biological Process	Immune System Process Receptor-mediated Endocytosis Defense Response Acute-phase Response Metabolic Process Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process	Proteolysis Complement Activation, Classical Pathway Innate Immune Response
Pathways		Scavenging of heme from plasma
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		20 interactors: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	2 interactors: HP SPP1
Entrez ID		3240	51279
HPRD ID		00772	07093
Ensembl ID		ENSG00000257017	ENSG00000139178
Uniprot IDs		P00738 Q6PEJ8	F5GWF3 Q9NZP8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Response To Stress Wound Healing Multicellular Organismal Development Response To Wounding Blood Coagulation Hemostasis Response To Stimulus Tissue Development Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune Response Defense Response Developmental Process Positive Regulation Of Cell Death Anatomical Structure Development Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Immune Response System Development Endocytosis Cellular Extravasation Activated T Cell Proliferation Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Reactive Oxygen Species Metabolic Process Cell Adhesion Organ Development Protein Oligomerization Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Gland Development Neutrophil Chemotaxis Positive Regulation Of Immune System Process Morphogenesis Of An Epithelium Neutrophil Migration Leukocyte Migration Single Organismal Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta3 Production Epidermal Cell Division Ectoderm And Mesoderm Interaction Granulocyte Chemotaxis Regulation Of Nitric Oxide Biosynthetic Process	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Hydrogen Peroxide Metabolic Process Inflammatory Response Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Negative Regulation Of Oxidoreductase Activity Positive Regulation Of Tissue Remodeling Regulation Of Response To Reactive Oxygen Species Decidualization Response To Vitamin D Regulation Of Bone Resorption Defense Response Acute-phase Response Maternal Placenta Development Regulation Of Bone Remodeling Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Response To Oxidative Stress Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Negative Regulation Of Axonogenesis Regulation Of Tissue Remodeling Response To External Stimulus Acute Inflammatory Response Biomineral Tissue Development Regulation Of Oxidoreductase Activity Embryo Implantation Maternal Process Involved In Female Pregnancy Negative Regulation Of Developmental Growth Extracellular Matrix Disassembly Negative Regulation Of Cell Morphogenesis Involved In Differentiation Immune System Process Leukocyte Chemotaxis Response To Vitamin Negative Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Response To Hydrogen Peroxide Regulation Of Cell Size Osteoblast Differentiation Negative Regulation Of Cell Projection Organization Negative Regulation Of Cell Growth Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Axonogenesis Cell Chemotaxis Defense Response To Bacterium
Tagcloud ?		antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Difference) ?		antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Intersection) ?