HP and C1RL

Number of citations of the paper that reports this interaction (PubMedID 15385675)
27

Data Source:
HPRD (in vitro)

		HP	C1RL
Description		haptoglobin	complement C1r subcomponent like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Defense Response Acute-phase Response Inflammatory Response Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Immune System Process Proteolysis Complement Activation, Classical Pathway Zymogen Activation Innate Immune Response
Pathways		Scavenging of heme from plasma Neutrophil degranulation
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Cholesterol, total ( 20686565 25961943) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 20686565 25961943) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)
Interacting Genes		21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	2 interacting genes: HP SPP1
Entrez ID		3240	51279
HPRD ID		00772	07093
Ensembl ID		ENSG00000257017	ENSG00000139178
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	F5GWF3 F5H7C8 Q6P672 Q9NZP8
PDB IDs		4WJG 4X0L 5HU6 6TB2 8XMP 8XMQ 8XMW 9FHB 9FMU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Integrin AlphaM-beta2 Complex Protein Phosphatase Binding Positive Regulation Of Neutrophil Degranulation Extracellular Exosome Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neutrophil Degranulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Complement Component C3b Binding Regulation Of Immune Response Protein Kinase Binding Protein Stabilization Protein Metabolic Process Endocytic Vesicle Lumen Response To Other Organism Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Response To Stress Ficolin-1-rich Granule Lumen Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Leukocyte Activation Integrin Complex Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Microglial Cell Activation Regulation Of Superoxide Metabolic Process Phagocytosis, Engulfment Response To External Biotic Stimulus Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Defense Response Endodermal Cell Differentiation Receptor-mediated Endocytosis Response To Cocaine	Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Hemoglobin Binding Androgen Catabolic Process Negative Regulation Of Hydrogen Peroxide Metabolic Process Cellular Response To Testosterone Stimulus Haptoglobin-hemoglobin Complex Positive Regulation Of Bone Resorption Response To Macrophage Colony-stimulating Factor Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Response To 2,3,7,8-tetrachlorodibenzodioxine Hormone Catabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Endocytic Vesicle Lumen Antioxidant Activity Regulation Of Collateral Sprouting Decidualization Small Molecule Binding Steroid Catabolic Process Androgen Metabolic Process Regulation Of Axon Regeneration Response To Vitamin D Regulation Of Neuron Projection Regeneration Extracellular Matrix Binding Zymogen Activation Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Bone Resorption Acute-phase Response Response To Testosterone Embryo Implantation Regulation Of Bone Remodeling Tertiary Granule Lumen Negative Regulation Of Axonogenesis Specific Granule Lumen Acute Inflammatory Response Extracellular Space Response To Vitamin Cellular Oxidant Detoxification Regulation Of Tissue Remodeling Positive Regulation Of Lipid Transport Response To Hydrogen Peroxide Negative Regulation Of Developmental Growth Biomineral Tissue Development Cellular Detoxification Extracellular Region Extracellular Exosome
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