HP and ATP7B

Number of citations of the paper that reports this interaction (PMID 16676348)
4

Data Source:
BioGRID (two hybrid)

		HP	ATP7B
Gene Name		haptoglobin	ATPase, Cu++ transporting, beta polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle	Golgi Membrane Mitochondrion Late Endosome Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Catalytic Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Copper-exporting ATPase Activity Copper Ion Binding Protein Binding ATP Binding
	Biological Process	Immune System Process Receptor-mediated Endocytosis Defense Response Acute-phase Response Metabolic Process Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process	Copper Ion Transport Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Lactation Metabolic Process Copper Ion Import Intracellular Copper Ion Transport Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Transmembrane Transport Copper Ion Export
Pathways		Scavenging of heme from plasma	Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		20 interactors: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	4 interactors: ATOX1 DCTN4 HP ZBTB16
Entrez ID		3240	540
HPRD ID		00772	06050
Ensembl ID		ENSG00000257017	ENSG00000123191
Uniprot IDs		P00738 Q6PEJ8	B7ZLR4 E7ET55 F5H562 F5H748 P35670
PDB IDs			2ARF 2EW9 2KOY 2LQB 2ROP
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Response To Stress Wound Healing Multicellular Organismal Development Response To Wounding Blood Coagulation Hemostasis Response To Stimulus Tissue Development Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune Response Defense Response Developmental Process Positive Regulation Of Cell Death Anatomical Structure Development Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Immune Response System Development Endocytosis Cellular Extravasation Activated T Cell Proliferation Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Reactive Oxygen Species Metabolic Process Cell Adhesion Organ Development Protein Oligomerization Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Gland Development Neutrophil Chemotaxis Positive Regulation Of Immune System Process Morphogenesis Of An Epithelium Neutrophil Migration Leukocyte Migration Single Organismal Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta3 Production Epidermal Cell Division Ectoderm And Mesoderm Interaction Granulocyte Chemotaxis Regulation Of Nitric Oxide Biosynthetic Process	Negative Regulation Of Hydrogen Peroxide Catabolic Process Response To Reactive Oxygen Species Intracellular Copper Ion Transport Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of NK T Cell Differentiation Male Germ-line Stem Cell Asymmetric Division Regulation Of Hydrogen Peroxide Metabolic Process Copper Ion Transmembrane Transport Response To Oxidative Stress Nuclear Migration Immune System Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Localization Positive Regulation Of Cell Death Negative Regulation Of Oxidoreductase Activity Establishment Of Nucleus Localization Copper Ion Transport Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Chondrocyte Differentiation
Tagcloud ?		antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4	abcb1 abcg2 arg72pro arg952lys asp1853asn atm backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 markabcb1 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Difference) ?		antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4	abcb1 abcg2 arg72pro arg952lys asp1853asn atm backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 markabcb1 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Intersection) ?