HP and ATP7B

Number of citations of the paper that reports this interaction (PubMedID 16676348)
0

Data Source:
BioGRID (two hybrid)

		HP	ATP7B
Description		haptoglobin	ATPase copper transporting beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Golgi Membrane Cytoplasm Mitochondrion Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Nucleotide Binding Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity P-type Divalent Copper Transporter Activity Metal Ion Binding P-type Monovalent Copper Transporter Activity
	Biological Process	Immune System Process Defense Response Acute-phase Response Inflammatory Response Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Monoatomic Ion Transport Monoatomic Cation Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Lactation Copper Ion Import Monoatomic Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Protein Maturation Establishment Of Localization In Cell Copper Ion Export Viral Translational Frameshifting Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Scavenging of heme from plasma Neutrophil degranulation	Ion transport by P-type ATPases
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases			Wilson disease; Hepatolenticular degeneration
GWAS		Cholesterol, total ( 20686565 25961943) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 20686565 25961943) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Clostridium difficile infection in multiple myeloma ( 29594489) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	4 interacting genes: ATOX1 DCTN4 HP ZBTB16
Entrez ID		3240	540
HPRD ID		00772	06050
Ensembl ID		ENSG00000257017	ENSG00000123191
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	A0A669KB88 A0AAQ5BGL6 A0AAQ5BGP2 B7ZLR3 B7ZLR4 E7ET55 F5H562 F5H748 P35670
PDB IDs		4WJG 4X0L 5HU6 6TB2 8XMP 8XMQ 8XMW 9FHB 9FMU	2ARF 2EW9 2KOY 2LQB 2N7Y 2ROP 6A71 6A72 7XUK 7XUM 7XUN 7XUO 8IOY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Integrin AlphaM-beta2 Complex Protein Phosphatase Binding Positive Regulation Of Neutrophil Degranulation Extracellular Exosome Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neutrophil Degranulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Complement Component C3b Binding Regulation Of Immune Response Protein Kinase Binding Protein Stabilization Protein Metabolic Process Endocytic Vesicle Lumen Response To Other Organism Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Response To Stress Ficolin-1-rich Granule Lumen Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Leukocyte Activation Integrin Complex Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Microglial Cell Activation Regulation Of Superoxide Metabolic Process Phagocytosis, Engulfment Response To External Biotic Stimulus Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Defense Response Endodermal Cell Differentiation Receptor-mediated Endocytosis Response To Cocaine	Copper-dependent Protein Binding Copper Ion Export Copper Chaperone Activity Metallochaperone Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Hemoglobin Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of NK T Cell Differentiation Copper Ion Transmembrane Transport Dynactin Complex Cuprous Ion Binding Ossification Involved In Bone Maturation Response To Oxidative Stress Haptoglobin-hemoglobin Complex Mesonephros Development Asymmetric Cell Division Copper Ion Transport Intracellular Copper Ion Homeostasis Regulation Of Hydrogen Peroxide Metabolic Process Endocytic Vesicle Lumen Copper Ion Homeostasis Positive Regulation Of Chondrocyte Differentiation Cytoplasmic Dynein Complex Stem Cell Division Antioxidant Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?