NREP and IGSF21

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NREP	IGSF21
Gene Name		neuronal regeneration related protein	immunoglobin superfamily, member 21
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region
	Molecular Function	Protein Binding
	Biological Process	Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Regulation Of Neuron Differentiation
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		3 interactors: EEF1A1 IGSF21 KMT2B	32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		9315	84966
HPRD ID		09545	11309
Ensembl ID		ENSG00000134986	ENSG00000117154
Uniprot IDs		Q16612	Q96ID5
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Trimethylation Positive Regulation Of Gene Expression, Epigenetic Ovulation Regulation Of Histone H3-K4 Methylation Cellular Response To Epidermal Growth Factor Stimulus Peptidyl-lysine Trimethylation Response To Epidermal Growth Factor Histone H3-K4 Methylation	Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth
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