KLF4 and HDAC5

Number of citations of the paper that reports this interaction (PubMedID 18768922)
27

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KLF4	HDAC5
Description		KLF transcription factor 4	histone deacetylase 5
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Microtubule Cytoskeleton	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Chromatin DNA Binding Phosphatidylinositol 3-kinase Regulator Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity Transcription Corepressor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Protein Lysine Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Defense Response To Tumor Cell DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mesodermal Cell Fate Determination Negative Regulation Of Cell Population Proliferation Epidermis Development Epidermal Cell Differentiation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Hyperplasia Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Negative Regulation Of Cell Migration Epithelial Cell Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Telomere Maintenance Response To Retinoic Acid Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Population Maintenance Post-embryonic Hemopoiesis Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axon Regeneration Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Establishment Of Skin Barrier Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blastocyst Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Inflammatory Response Response To Xenobiotic Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Response To Cocaine Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells FOXO-mediated transcription of cell cycle genes Positive Regulation of CDH1 Gene Transcription	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Breast cancer ( 21263130) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 33020668) Cotinine glucuronidation ( 25293881) Cutaneous malignant melanoma ( 26237428) Glycated hemoglobin levels ( 34059833 28898252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Myocardial infarction ( 33532862) Prostate cancer ( 23023329) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Takayasu arteritis ( 25604533) Tenofovir clearance in HIV infection ( 26148204)	Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756 33263727 34002096) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Mean platelet volume ( 32888494)
Interacting Genes		24 interacting genes: APP CREBBP DVL3 ELK1 FBXO7 GYS1 HDAC1 HDAC5 HGS HSF2BP KAT5 KLF6 LINC00629 MYO15B PAX9 PLK1 SETD7 SP1 TLE5 TP53 USP10 USP17L2 VHL ZNF750	60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE ZBTB16
Entrez ID		9314	10014
HPRD ID		03769	09246
Ensembl ID		ENSG00000136826	ENSG00000108840
Uniprot IDs		O43474	Q9UQL6
PDB IDs		6VTX	5UWI 8Q9P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Binding Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Double-strand Break Repair Regulation Of Programmed Cell Death Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Histone Deacetylase Binding Regulation Of Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm DNA Damage Response, Signal Transduction By P53 Class Mediator Autophagy Negative Regulation Of Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Repair	Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Binding Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Transcription Coregulator Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Histone Deacetylase Complex Regulation Of MiRNA Transcription Regulation Of Nucleocytoplasmic Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?