KLF4 and ZNF750

Number of citations of the paper that reports this interaction (PubMedID 25228645)
42

Data Source:
BioGRID (far western blotting)

		KLF4	ZNF750
Description		KLF transcription factor 4	zinc finger protein 750
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Microtubule Cytoskeleton	Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Chromatin DNA Binding Phosphatidylinositol 3-kinase Regulator Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Defense Response To Tumor Cell DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mesodermal Cell Fate Determination Negative Regulation Of Cell Population Proliferation Epidermis Development Epidermal Cell Differentiation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Hyperplasia Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Negative Regulation Of Cell Migration Epithelial Cell Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Telomere Maintenance Response To Retinoic Acid Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Population Maintenance Post-embryonic Hemopoiesis Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axon Regeneration Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Establishment Of Skin Barrier Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blastocyst Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Epidermis Development Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Membrane Biogenesis Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Skin Barrier Positive Regulation Of Ceramide Biosynthetic Process
Pathways		Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells FOXO-mediated transcription of cell cycle genes Positive Regulation of CDH1 Gene Transcription	Generic Transcription Pathway
Drugs
Diseases			Seborrhea-like dermatitis with psoriasiform element
GWAS		Breast cancer ( 21263130) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 33020668) Cotinine glucuronidation ( 25293881) Cutaneous malignant melanoma ( 26237428) Glycated hemoglobin levels ( 34059833 28898252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Myocardial infarction ( 33532862) Prostate cancer ( 23023329) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Takayasu arteritis ( 25604533) Tenofovir clearance in HIV infection ( 26148204)	Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309)
Interacting Genes		24 interacting genes: APP CREBBP DVL3 ELK1 FBXO7 GYS1 HDAC1 HDAC5 HGS HSF2BP KAT5 KLF6 LINC00629 MYO15B PAX9 PLK1 SETD7 SP1 TLE5 TP53 USP10 USP17L2 VHL ZNF750	5 interacting genes: CTBP1 CTBP2 KDM1A KLF4 RCOR1
Entrez ID		9314	79755
HPRD ID		03769	08588
Ensembl ID		ENSG00000136826	ENSG00000141579
Uniprot IDs		O43474	Q32MQ0
PDB IDs		6VTX	8SXM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Binding Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Double-strand Break Repair Regulation Of Programmed Cell Death Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Histone Deacetylase Binding Regulation Of Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm DNA Damage Response, Signal Transduction By P53 Class Mediator Autophagy Negative Regulation Of Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Repair	Transcription Corepressor Activity Transcription Coregulator Binding Transcription Repressor Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Fat Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Complex White Fat Cell Differentiation DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Viral Genome Replication LncRNA Binding Transcription Regulator Complex Histone Methyltransferase Complex Negative Regulation Of Macromolecule Biosynthetic Process NAD Binding Negative Regulation Of Biosynthetic Process Transcription Coactivator Activity Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Corepressor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Negative Regulation Of Metabolic Process Cellular Developmental Process Promoter-specific Chromatin Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Oxidoreductase Activity RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Hyperplasia Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Cell Population Proliferation Viral Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Blastocyst Development Mesodermal Cell Fate Determination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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