KLF4 and USP17L2

Number of citations of the paper that reports this interaction (PubMedID 35383144)
41

Data Source:
BioGRID (enzymatic study)

		KLF4	USP17L2
Description		KLF transcription factor 4	ubiquitin specific peptidase 17 like family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Microtubule Cytoskeleton	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Chromatin DNA Binding Phosphatidylinositol 3-kinase Regulator Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Defense Response To Tumor Cell DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mesodermal Cell Fate Determination Negative Regulation Of Cell Population Proliferation Epidermis Development Epidermal Cell Differentiation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Hyperplasia Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Negative Regulation Of Cell Migration Epithelial Cell Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Telomere Maintenance Response To Retinoic Acid Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Population Maintenance Post-embryonic Hemopoiesis Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axon Regeneration Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Establishment Of Skin Barrier Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blastocyst Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Proteolysis Apoptotic Process Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of GTPase Activity Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells FOXO-mediated transcription of cell cycle genes Positive Regulation of CDH1 Gene Transcription	Ub-specific processing proteases RAS processing
Drugs
Diseases
GWAS		Breast cancer ( 21263130) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 33020668) Cotinine glucuronidation ( 25293881) Cutaneous malignant melanoma ( 26237428) Glycated hemoglobin levels ( 34059833 28898252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Myocardial infarction ( 33532862) Prostate cancer ( 23023329) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Takayasu arteritis ( 25604533) Tenofovir clearance in HIV infection ( 26148204)
Interacting Genes		24 interacting genes: APP CREBBP DVL3 ELK1 FBXO7 GYS1 HDAC1 HDAC5 HGS HSF2BP KAT5 KLF6 LINC00629 MYO15B PAX9 PLK1 SETD7 SP1 TLE5 TP53 USP10 USP17L2 VHL ZNF750	11 interacting genes: BRD4 CDK4 CDK6 ELK1 KLF4 KMT5A LGMN LINC02487 SIRT7 UBC ZBTB7A
Entrez ID		9314	377630
HPRD ID		03769	16844
Ensembl ID		ENSG00000136826	ENSG00000223443
Uniprot IDs		O43474	Q6R6M4
PDB IDs		6VTX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Binding Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Double-strand Break Repair Regulation Of Programmed Cell Death Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Histone Deacetylase Binding Regulation Of Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm DNA Damage Response, Signal Transduction By P53 Class Mediator Autophagy Negative Regulation Of Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Repair	Regulation Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle G2/M Phase Transition Cyclin Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Chromatin Remodeling Histone H4K8ac Reader Activity Nucleolus Organizer Region Polytene Chromosome Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Response To Growth Factor Negative Regulation Of Signal Transduction
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