NAPRT and CCDC57

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NAPRT	CCDC57
Gene Name		nicotinate phosphoribosyltransferase	coiled-coil domain containing 57
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Nicotinate Phosphoribosyltransferase Activity Ligase Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Response To Oxidative Stress NAD Biosynthetic Process Nicotinate Nucleotide Salvage NAD Metabolic Process Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CCDC57 EHMT2 GRAMD3 KRT40 RBPMS	42 interactors: AES AQP1 ARL4A CBX8 CCDC120 CDC20B CEP57L1 CWF19L2 FAM161A FAM50B FAM90A1 GPKOW HAUS1 HBA2 KIAA0368 LENG1 LINC00526 MFAP1 NAPRT NELFE NUMA1 PER1 PPHLN1 PPP1R18 PRAM1 PRPF31 PRR3 PTPN7 RAB3IL1 ROBO3 SFI1 SIRPA TBC1D22B TMEM100 TSGA10IP USP15 USP2 UTP14C ZFC3H1 ZGPAT ZMAT2 ZNF417
Entrez ID		93100	284001
HPRD ID		15161	14150
Ensembl ID		ENSG00000147813	ENSG00000176155
Uniprot IDs		Q6XQN6	Q2TAC2
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Within A CG Sequence Histone H3-K27 Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Histone H3-K9 Methylation Synaptonemal Complex Assembly Synaptonemal Complex Organization Histone H3-K9 Modification	Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription From RNA Polymerase II Promoter Photoperiodism Entrainment Of Circadian Clock Bicarbonate Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Nicotinate Nucleotide Salvage
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