NAPRT and EHMT2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NAPRT	EHMT2
Gene Name		nicotinate phosphoribosyltransferase	euchromatic histone-lysine N-methyltransferase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Nicotinate Phosphoribosyltransferase Activity Ligase Activity	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Response To Oxidative Stress NAD Biosynthetic Process Nicotinate Nucleotide Salvage NAD Metabolic Process Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Replication DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Histone H3-K27 Methylation
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism	Chromatin modifying enzymes Chromatin organization RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation PKMTs methylate histone lysines RNA Polymerase I Promoter Clearance Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS			Chronic hepatitis B infection ( 23760081) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239)
Protein-Protein Interactions		5 interactors: CCDC57 EHMT2 GRAMD3 KRT40 RBPMS	42 interactors: C10orf12 CACNA1A CBX1 CCDC33 CHCHD2 CUX1 DNMT3A E4F1 ESR1 FAM161A H3F3B HGS HIST1H1A HIST1H1B HIST1H3A HIST2H3A HIST2H3C HIST3H3 ITGB5 KLF12 KLF3 KLF6 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 PRRC2B PSMA1 RD3 RELB RERE RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF785
Entrez ID		93100	10919
HPRD ID		15161	06854
Ensembl ID		ENSG00000147813	ENSG00000204371
Uniprot IDs		Q6XQN6	A2ABF8 A2ABF9 Q96KQ7
PDB IDs			2O8J 3DM1 3K5K 3RJW
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Within A CG Sequence Histone H3-K27 Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Histone H3-K9 Methylation Synaptonemal Complex Assembly Synaptonemal Complex Organization Histone H3-K9 Modification	DNA Methylation On Cytosine Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Silencing At RDNA DNA Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Regulation Of Metabolic Process Chromosome Organization DNA Modification DNA Packaging Transcription, DNA-templated Gene Silencing RNA Biosynthetic Process Chromatin Organization Chromatin Assembly Chromatin Assembly Or Disassembly Positive Regulation Of Gene Expression Cellular Component Assembly Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Establishment Of Protein Localization To Chromatin RNA Metabolic Process Nucleosome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleosome Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Protein-DNA Complex Assembly Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Tagcloud ?			availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Difference) ?			availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Intersection) ?