NAPRT and GRAMD3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NAPRT	GRAMD3
Gene Name		nicotinate phosphoribosyltransferase	GRAM domain containing 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Vesicular Exosome	Cytoplasmic Microtubule
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Nicotinate Phosphoribosyltransferase Activity Ligase Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Response To Oxidative Stress NAD Biosynthetic Process Nicotinate Nucleotide Salvage NAD Metabolic Process Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS			Cognitive performance ( 20125193) Diabetic retinopathy ( 21441570)
Protein-Protein Interactions		5 interactors: CCDC57 EHMT2 GRAMD3 KRT40 RBPMS	6 interactors: ABO FRMD8 GIMAP5 MORF4L2 NAPRT PAEP
Entrez ID		93100	65983
HPRD ID		15161	11402
Ensembl ID		ENSG00000147813	ENSG00000155324
Uniprot IDs		Q6XQN6	Q96HH9
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Within A CG Sequence Histone H3-K27 Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Histone H3-K9 Methylation Synaptonemal Complex Assembly Synaptonemal Complex Organization Histone H3-K9 Modification	Nicotinate Nucleotide Salvage Nicotinamide Metabolic Process Alkaloid Metabolic Process
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