LGALS3BP and PPIC

Number of citations: 50 (PubMedID 10077627)
Data Source: HPRD (in vitro)

		LGALS3BP	PPIC
Name		galectin 3 binding protein	peptidylprolyl isomerase C
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome Blood Microparticle	Cytoplasm Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Scavenger Receptor Activity Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity
	Biological Process	Cellular Defense Response Cell Adhesion Signal Transduction Vesicle-mediated Transport	Protein Folding
Pathways		Platelet degranulation	None
Drugs		None	Proline
GWAS		Blood protein levels ( 30072576 )	Aortic root size ( 19584346 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Diverticular disease ( 30177863 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		None recorded	1 novel interactors: TRAF7
Interacting Genes		24 interacting genes: CD14 COL5A1 COL6A1 FBXO7 FN1 GALNT6 HSP90AA1 ITGA5 ITGA6 ITGAV ITGB1 LGALS1 LGALS3 NID1 PPIC SELE SIGLEC10 SIGLEC11 SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC9 WNT4 XRN1	13 interacting genes: ARSA BANP CAPNS2 FAM25A FAM25C FAM25G LGALS3BP SGTA SGTB UBAP1 UBQLN1 UBQLN2 UBQLN4
Entrez ID		3959	5480
HPRD ID		02796	00459
Ensembl ID		ENSG00000108679	ENSG00000168938
Uniprot IDs		Q08380	P45877
PDB IDs		1BY2 6GFB	2ESL
GO Terms Enriched among Interactors		Cell Adhesion Sialic Acid Binding Carbohydrate Binding Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Laminin Binding Integrin Complex Cell-substrate Adhesion Wound Healing, Spreading Of Cells Response To Muscle Activity Endodermal Cell Differentiation Integrin-mediated Signaling Pathway Proteoglycan Binding Regulation Of Cellular Component Organization Plasma Membrane Extracellular Matrix Cell Surface Cell Migration Integrin Binding Integrin Alpha6-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Response To Activity Positive Regulation Of Cell Adhesion Cell Motility Basement Membrane Positive Regulation Of Cell Migration Regulation Of Locomotion Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Secretory Granule Membrane Positive Regulation Of Cell Motility Calcium-independent Cell-matrix Adhesion Positive Regulation Of Locomotion Basement Membrane Organization Negative Regulation Of Apoptotic Signaling Pathway Heterotypic Cell-cell Adhesion Neuregulin Binding C-X3-C Chemokine Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Dendritic Cell Differentiation Signaling Receptor Activity Regulation Of Cell Migration Cell-cell Adhesion Mediated By Integrin Extracellular Exosome Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Cell Motility	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Cerebroside-sulfatase Activity Regulation Of Cellular Response To Stress Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Targeting To Membrane Identical Protein Binding Autophagy Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Proteolysis Establishment Of Protein Localization To Organelle Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Autophagosome Assembly BAT3 Complex Binding Autophagosome Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Autophagy Calpain Complex Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Vesicle Cytosolic Proteasome Complex Regulation Of Protein Metabolic Process Negative Regulation Of ERAD Pathway