LGALS3BP and SIGLEC7

Number of citations of the paper that reports this interaction (PubMedID 25320078)
66

Data Source:
BioGRID (pull down)

		LGALS3BP	SIGLEC7
Description		galectin 3 binding protein	sialic acid binding Ig like lectin 7
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome Blood Microparticle	Plasma Membrane Membrane
	Molecular Function	Scavenger Receptor Activity Protein Binding	Protein Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Cellular Defense Response Cell Adhesion Signal Transduction Vesicle-mediated Transport	Cell Adhesion
Pathways		Platelet degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			N-acetyl-alpha-D-glucosamine
Diseases
GWAS		Blood protein levels ( 30072576)	High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		24 interacting genes: CD14 COL5A1 COL6A1 FBXO7 FN1 GALNT6 HSP90AA1 ITGA5 ITGA6 ITGAV ITGB1 LGALS1 LGALS3 NID1 PPIC SELE SIGLEC10 SIGLEC11 SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC9 WNT4 XRN1	5 interacting genes: GRB2 LGALS3BP PTPN11 SMIM1 TRAF4
Entrez ID		3959	27036
HPRD ID		02796	05102
Ensembl ID		ENSG00000108679	ENSG00000168995
Uniprot IDs		Q08380	Q9Y286
PDB IDs		1BY2 6GFB	1NKO 1O7S 1O7V 2DF3 2G5R 2HRL
Enriched GO Terms of Interacting Partners?		Cell Adhesion Sialic Acid Binding Carbohydrate Binding Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Laminin Binding Integrin Complex Cell-substrate Adhesion Wound Healing, Spreading Of Cells Response To Muscle Activity Endodermal Cell Differentiation Integrin-mediated Signaling Pathway Proteoglycan Binding Regulation Of Cellular Component Organization Plasma Membrane Extracellular Matrix Cell Surface Cell Migration Integrin Binding Integrin Alpha6-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Response To Activity Positive Regulation Of Cell Adhesion Cell Motility Basement Membrane Positive Regulation Of Cell Migration Regulation Of Locomotion Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Secretory Granule Membrane Positive Regulation Of Cell Motility Calcium-independent Cell-matrix Adhesion Positive Regulation Of Locomotion Basement Membrane Organization Negative Regulation Of Apoptotic Signaling Pathway Heterotypic Cell-cell Adhesion Neuregulin Binding C-X3-C Chemokine Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Dendritic Cell Differentiation Signaling Receptor Activity Regulation Of Cell Migration Cell-cell Adhesion Mediated By Integrin Extracellular Exosome Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Cell Motility	Phosphotyrosine Residue Binding T Cell Costimulation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding ERBB Signaling Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of MAPK Cascade Grb2-EGFR Complex Intestinal Epithelial Cell Migration Signal Transduction In Response To DNA Damage Cerebellar Cortex Formation Negative Regulation Of Glucocorticoid Secretion Neurotrophin TRKA Receptor Binding Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Platelet Dense Granule Lumen Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrioventricular Canal Development Microvillus Organization Regulation Of Neutrophil Activation Regulation Of Growth Hormone Secretion Peptide Hormone Receptor Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Bergmann Glial Cell Differentiation Neutrophil Activation Involved In Immune Response Thioesterase Binding Respiratory Tube Development
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