GJB2 and GJB1

Number of citations of the paper that reports this interaction (PMID 9592087)
10

Data Source:
HPRD (in vivo)

		GJB2	GJB1
Gene Name		gap junction protein, beta 2, 26kDa	gap junction protein, beta 1, 32kDa
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Connexon Complex Integral Component Of Membrane Lateral Plasma Membrane	Endoplasmic Reticulum Membrane Connexon Complex Integral Component Of Membrane
	Molecular Function	Gap Junction Channel Activity	Protein Homodimerization Activity
	Biological Process	Transport Cell-cell Signaling Sensory Perception Of Sound Gap Junction Assembly Male Genitalia Development Response To Estradiol Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Decidualization Transmembrane Transport Membrane Organization	Transport Cell-cell Signaling Nervous System Development Gap Junction Assembly Membrane Organization
Pathways		Transport of connexons to the plasma membrane Gap junction assembly Transport of connexins along the secretory pathway Gap junction trafficking and regulation Gap junction trafficking Oligomerization of connexins into connexons	Gap junction assembly Transport of connexins along the secretory pathway Gap junction trafficking and regulation Gap junction trafficking Oligomerization of connexins into connexons
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CAV1 CD14 CNST GJB1 GJB6	8 interactors: APP CALM1 CNST GJB2 PRKACA PRKCA SRC VKORC1
Entrez ID		2706	2705
HPRD ID		00413	02367
Ensembl ID		ENSG00000165474	ENSG00000169562
Uniprot IDs		H9U1J4 P29033	P08034
PDB IDs		1XIR 2ZW3 3IZ1 3IZ2	1TXH
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Regulation Of Vesicle-mediated Transport Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transport Nitric Oxide Homeostasis Response To Lipid Regulation Of Endocytosis Positive Regulation Of Golgi To Plasma Membrane Protein Transport Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis Cell Death Death Response To Abiotic Stimulus Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Mammary Gland Involution Positive Regulation Of Intracellular Transport Protein Localization To Plasma Membrane Raft Positive Regulation Of Metalloenzyme Activity Caveola Assembly Regulation Of Cardiac Muscle Cell Action Potential Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Lipopolysaccharide Negative Regulation Of Nitric-oxide Synthase Activity Response To Metal Ion Response To Molecule Of Bacterial Origin Cellular Response To Hyperoxia Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Transport Membrane Raft Assembly Protein Localization To Membrane Raft Negative Regulation Of Monooxygenase Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Lipoteichoic Acid Negative Regulation Of Anoikis Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Intracellular Transport Response To Magnesium Ion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Anoikis Response To Inorganic Substance	Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Dense Core Granule Biogenesis Rhodopsin Mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Fibroblast Growth Factor Stimulus Histone H3-T6 Phosphorylation Response To Fibroblast Growth Factor Positive Regulation Of Lyase Activity Cell-cell Junction Organization Neurotrophin TRK Receptor Signaling Pathway Activation Of Phospholipase C Activity Neurotrophin Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Cell Activation Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phospholipase Activity Phototransduction, Visible Light Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Innate Immune Response Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Interleukin-1 Regulation Of Phospholipase Activity Regulation Of CAMP Biosynthetic Process Response To Light Stimulus Positive Regulation Of Lipase Activity Detection Of Visible Light Membrane Organization
Tagcloud ?		12s audiometry brainstem clinics counseling deaf deafness del etiologies gjb3 guidance hearing hereditary heterozygous homozygous hot liaoning mutation occupies profound questionnaires rrna slc26a4 spot syndromic templates theoretical tone tympanometry	aberrantly aberration ap1s2 brcc3 cpxcr1 cxorf45 ddx53 dmd fam9a fhl1 gabre hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist
Tagcloud (Difference) ?		12s audiometry brainstem clinics counseling deaf deafness del etiologies gjb3 guidance hearing hereditary heterozygous homozygous hot liaoning mutation occupies profound questionnaires rrna slc26a4 spot syndromic templates theoretical tone tympanometry	aberrantly aberration ap1s2 brcc3 cpxcr1 cxorf45 ddx53 dmd fam9a fhl1 gabre hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist
Tagcloud (Intersection) ?