GJB2 and GJB6

Number of citations of the paper that reports this interaction (PMID 14595769)
50

Data Source:
HPRD (in vivo)

		GJB2	GJB6
Gene Name		gap junction protein, beta 2, 26kDa	gap junction protein, beta 6, 30kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Connexon Complex Integral Component Of Membrane Lateral Plasma Membrane	Cytosol Connexon Complex Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Gap Junction Channel Activity
	Biological Process	Transport Cell-cell Signaling Sensory Perception Of Sound Gap Junction Assembly Male Genitalia Development Response To Estradiol Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Decidualization Transmembrane Transport Membrane Organization	Apoptotic Process Cell Communication Aging Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Response To Lipopolysaccharide Ear Morphogenesis Inner Ear Development Response To Electrical Stimulus Cellular Response To Glucose Stimulus
Pathways		Transport of connexons to the plasma membrane Gap junction assembly Transport of connexins along the secretory pathway Gap junction trafficking and regulation Gap junction trafficking Oligomerization of connexins into connexons	Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CAV1 CD14 CNST GJB1 GJB6	2 interactors: CNST GJB2
Entrez ID		2706	10804
HPRD ID		00413	05107
Ensembl ID		ENSG00000165474	ENSG00000121742
Uniprot IDs		H9U1J4 P29033	O95452
PDB IDs		1XIR 2ZW3 3IZ1 3IZ2
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Regulation Of Vesicle-mediated Transport Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transport Nitric Oxide Homeostasis Response To Lipid Regulation Of Endocytosis Positive Regulation Of Golgi To Plasma Membrane Protein Transport Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis Cell Death Death Response To Abiotic Stimulus Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Mammary Gland Involution Positive Regulation Of Intracellular Transport Protein Localization To Plasma Membrane Raft Positive Regulation Of Metalloenzyme Activity Caveola Assembly Regulation Of Cardiac Muscle Cell Action Potential Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Lipopolysaccharide Negative Regulation Of Nitric-oxide Synthase Activity Response To Metal Ion Response To Molecule Of Bacterial Origin Cellular Response To Hyperoxia Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Transport Membrane Raft Assembly Protein Localization To Membrane Raft Negative Regulation Of Monooxygenase Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Lipoteichoic Acid Negative Regulation Of Anoikis Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Intracellular Transport Response To Magnesium Ion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Anoikis Response To Inorganic Substance	Response To Human Chorionic Gonadotropin Positive Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Gap Junction Assembly Positive Regulation Of Protein Localization To Plasma Membrane Male Genitalia Development Decidualization Regulation Of Establishment Of Protein Localization To Plasma Membrane Maternal Placenta Development Response To Gonadotropin Response To Progesterone Regulation Of Protein Localization To Plasma Membrane Genitalia Development Negative Regulation Of Phosphatase Activity Negative Regulation Of Dephosphorylation Maternal Process Involved In Female Pregnancy Regulation Of Phosphatase Activity
Tagcloud ?		12s audiometry brainstem clinics counseling deaf deafness del etiologies gjb3 guidance hearing hereditary heterozygous homozygous hot liaoning mutation occupies profound questionnaires rrna slc26a4 spot syndromic templates theoretical tone tympanometry	absent adversely clonogenic cohorts connexin connexins cx cx30 deleted escape gap genotoxic glioblastoma glioblastomas immunodeficient immunoreactivity invariably junction ominous proprietary protect radiation radioprotection repositories restoration striatum suppressors underline xenografts
Tagcloud (Difference) ?		12s audiometry brainstem clinics counseling deaf deafness del etiologies gjb3 guidance hearing hereditary heterozygous homozygous hot liaoning mutation occupies profound questionnaires rrna slc26a4 spot syndromic templates theoretical tone tympanometry	absent adversely clonogenic cohorts connexin connexins cx cx30 deleted escape gap genotoxic glioblastoma glioblastomas immunodeficient immunoreactivity invariably junction ominous proprietary protect radiation radioprotection repositories restoration striatum suppressors underline xenografts
Tagcloud (Intersection) ?