GJB2 and CD14

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GJB2	CD14
Gene Name		gap junction protein, beta 2, 26kDa	CD14 molecule
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Connexon Complex Integral Component Of Membrane Lateral Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Endosome Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Gap Junction Channel Activity	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Receptor Activity Lipoteichoic Acid Binding
	Biological Process	Transport Cell-cell Signaling Sensory Perception Of Sound Gap Junction Assembly Male Genitalia Development Response To Estradiol Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Decidualization Transmembrane Transport Membrane Organization	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Response To Magnesium Ion Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Positive Regulation Of Cytokine Secretion Response To Electrical Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid
Pathways		Transport of connexons to the plasma membrane Gap junction assembly Transport of connexins along the secretory pathway Gap junction trafficking and regulation Gap junction trafficking Oligomerization of connexins into connexons	TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Transfer of LPS from LBP carrier to CD14 Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CAV1 CD14 CNST GJB1 GJB6	14 interactors: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		2706	929
HPRD ID		00413	01151
Ensembl ID		ENSG00000165474	ENSG00000170458
Uniprot IDs		H9U1J4 P29033	P08571
PDB IDs		1XIR 2ZW3 3IZ1 3IZ2	4GLP
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Regulation Of Vesicle-mediated Transport Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transport Nitric Oxide Homeostasis Response To Lipid Regulation Of Endocytosis Positive Regulation Of Golgi To Plasma Membrane Protein Transport Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis Cell Death Death Response To Abiotic Stimulus Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Mammary Gland Involution Positive Regulation Of Intracellular Transport Protein Localization To Plasma Membrane Raft Positive Regulation Of Metalloenzyme Activity Caveola Assembly Regulation Of Cardiac Muscle Cell Action Potential Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Lipopolysaccharide Negative Regulation Of Nitric-oxide Synthase Activity Response To Metal Ion Response To Molecule Of Bacterial Origin Cellular Response To Hyperoxia Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Transport Membrane Raft Assembly Protein Localization To Membrane Raft Negative Regulation Of Monooxygenase Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Lipoteichoic Acid Negative Regulation Of Anoikis Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Intracellular Transport Response To Magnesium Ion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Anoikis Response To Inorganic Substance	Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Other Organism Response To Biotic Stimulus Macrophage Activation Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Response To Bacterium Defense Response Regulation Of Inflammatory Response Positive Regulation Of Immune System Process Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Chemokine Production Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune Response Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Response To Stress Defense Response To Bacterium Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Inflammatory Response Detection Of Molecule Of Bacterial Origin Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Response To External Stimulus I-kappaB Phosphorylation Negative Regulation Of Cytokine Production Innate Immune Response Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Import Into Nucleus Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		12s audiometry brainstem clinics counseling deaf deafness del etiologies gjb3 guidance hearing hereditary heterozygous homozygous hot liaoning mutation occupies profound questionnaires rrna slc26a4 spot syndromic templates theoretical tone tympanometry	1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
Tagcloud (Difference) ?		12s audiometry brainstem clinics counseling deaf deafness del etiologies gjb3 guidance hearing hereditary heterozygous homozygous hot liaoning mutation occupies profound questionnaires rrna slc26a4 spot syndromic templates theoretical tone tympanometry	1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
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