GJB2 and GJA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB2	GJA5
Description		gap junction protein beta 2	gap junction protein alpha 5
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Membrane Cell Projection Anchoring Junction
	Molecular Function	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Gap Junction Channel Activity Protein Binding Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Disordered Domain Specific Binding
	Biological Process	Cell Communication Cell-cell Signaling Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Transmembrane Transport Gap Junction-mediated Intercellular Transport	Skeletal System Development Angiogenesis Blood Vessel Development Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Septum Primum Development Atrial Ventricular Junction Remodeling Potassium Ion Transport Cell Communication Cell-cell Signaling Heart Development Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Embryonic Limb Morphogenesis Embryonic Heart Tube Development Foramen Ovale Closure Vasodilation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Artery Morphogenesis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Cardiac Conduction Ventricular Cardiac Muscle Cell Action Potential SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication Involved In Cardiac Conduction AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of AV Node Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Purkinje Myocyte Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vasomotion
Pathways		Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane	Gap junction assembly
Drugs
Diseases		Deafness, autosomal recessive Keratitis-ichthyosis-deafness syndrome Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis Deafness, autosomal dominant Palmoplantar keratoderma with deafness	Atrial fibrillation
GWAS		Facial emotion recognition (happy faces) ( 28608620)	Atrial fibrillation ( 29892015 30061737) Cognitive performance ( 20125193) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057) PR interval ( 32439900) Triglyceride levels ( 34074324)
Interacting Genes		44 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E PEX12 PLEKHB2 SAR1A SHISAL1 SLC10A6 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR	34 interacting genes: AAR2 ABHD16A ARLN BLCAP EMP3 FCER1G GJA1 GJB2 IGFBP5 LEPROT LEPROTL1 LHFPL2 MARK1 MS4A13 NIPAL3 NKG7 PGAP2 PRAF2 PRKACA RIMS3 RPRM SLC13A4 SLC30A2 SLC35F1 SLC41A1 SLC41A2 SLC61A1 SLC66A1 TMBIM6 TMEM107 TREX1 UBQLN4 VRK2 YIPF6
Entrez ID		2706	2702
HPRD ID		00413	08699
Ensembl ID		ENSG00000165474	ENSG00000265107
Uniprot IDs		H9U1J4 P29033	P36382 X5D2H9
PDB IDs		2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT 7QEO 7QEQ 7QER 7QES 7QET 7QEU 7QEV 7QEW 7QEY 8Q9Z 8QA0 8QA1 8QA2 8QA3
Enriched GO Terms of Interacting Partners?		Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Gap Junction Assembly Protein Binding Plasma Membrane Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Vasoconstriction Connexin Binding Atrioventricular Valve Development Gap Junction-mediated Intercellular Transport Regulation Of Gap Junction Assembly Intercellular Transport G Protein-coupled Receptor Activity Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Transmembrane Transport Regulation Of Vasoconstriction	Membrane Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Transmembrane Transport Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Inorganic Cation Transmembrane Transporter Activity Gap Junction Assembly Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Protein Binding Monoatomic Ion Transport Transmembrane Transporter Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Monoatomic Ion Transmembrane Transport Connexin Complex Gap Junction Channel Activity
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