HELB and POLA2

Number of citations of the paper that reports this interaction (PubMedID 12181327)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		HELB	POLA2
Description		DNA helicase B	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Cytoplasm Mitochondrion Cytosol Nuclear Body Site Of Double-strand Break	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body
	Molecular Function	Nucleotide Binding DNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Protein-containing Complex Binding	DNA Binding Protein Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Repair DNA Damage Response Regulation Of DNA Double-strand Break Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs			Dacarbazine
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Menopause (age at onset) ( 26414677) White blood cell count (basophil) ( 27863252 29403010)	Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		3 interacting genes: POLA1 POLA2 RPA1	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		92797	23649
HPRD ID		09979	10160
Ensembl ID		ENSG00000127311	ENSG00000014138
Uniprot IDs		F5H1I4 Q8NG08	A0A9L9PY44 H0YDR7 Q14181
PDB IDs		7XV1	2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication DNA Replication Initiation Nucleotide-excision Repair DNA-templated DNA Replication DNA Metabolic Process DNA Biosynthetic Process Single-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process Double-strand Break Repair Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Macromolecule Biosynthetic Process Leading Strand Elongation Single-stranded Telomeric DNA Binding Nucleic Acid Metabolic Process DNA Binding G-rich Strand Telomeric DNA Binding DNA Strand Elongation Involved In DNA Replication Chromatin Binding DNA Replication Factor A Complex Lateral Element DNA Polymerase Activity DNA Repair DNA Replication Origin Binding DNA Strand Elongation Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Chromatin-protein Adaptor Activity DNA-directed DNA Polymerase Activity Telomere Maintenance Via Telomerase Protein Localization To Organelle RNA-templated DNA Biosynthetic Process Protein Localization To Site Of Double-strand Break Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Mismatch Repair DNA Damage Response Condensed Chromosome Base-excision Repair Homeostasis Of Number Of Cells Within A Tissue DNA Synthesis Involved In DNA Repair Site Of DNA Damage Condensed Nuclear Chromosome Male Germ Cell Nucleus Double-strand Break Repair Via Nonhomologous End Joining Damaged DNA Binding Nucleoplasm	DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process
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