HELB

Description		DNA helicase B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Cytoplasm Mitochondrion Cytosol Nuclear Body Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Protein-containing Complex Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Repair DNA Damage Response Regulation Of DNA Double-strand Break Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Menopause (age at onset) ( 26414677) White blood cell count (basophil) ( 27863252 29403010)
Interacting Genes		3 interacting genes: POLA1 POLA2 RPA1
Entrez ID		92797
HPRD ID		09979
Ensembl ID		ENSG00000127311
Uniprot IDs		F5H1I4 Q8NG08
PDB IDs		7XV1
Enriched GO Terms of Interacting Partners?		Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication DNA Replication Initiation Nucleotide-excision Repair DNA-templated DNA Replication DNA Metabolic Process DNA Biosynthetic Process Single-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process Double-strand Break Repair Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Macromolecule Biosynthetic Process Leading Strand Elongation Single-stranded Telomeric DNA Binding Nucleic Acid Metabolic Process DNA Binding G-rich Strand Telomeric DNA Binding DNA Strand Elongation Involved In DNA Replication Chromatin Binding DNA Replication Factor A Complex Lateral Element DNA Polymerase Activity DNA Repair DNA Replication Origin Binding DNA Strand Elongation Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Chromatin-protein Adaptor Activity DNA-directed DNA Polymerase Activity Telomere Maintenance Via Telomerase Protein Localization To Organelle RNA-templated DNA Biosynthetic Process Protein Localization To Site Of Double-strand Break Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Mismatch Repair DNA Damage Response Condensed Chromosome Base-excision Repair Homeostasis Of Number Of Cells Within A Tissue DNA Synthesis Involved In DNA Repair Site Of DNA Damage Condensed Nuclear Chromosome Male Germ Cell Nucleus Double-strand Break Repair Via Nonhomologous End Joining Damaged DNA Binding Nucleoplasm
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