HELB and RPA1

Number of citations of the paper that reports this interaction (PubMedID 37827155)
181

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology)
HPRD (in vitro)

		HELB	RPA1
Description		DNA helicase B	replication protein A1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Cytoplasm Mitochondrion Cytosol Nuclear Body Site Of Double-strand Break	Nuclear Chromosome Chromosome, Telomeric Region Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Nucleotide Binding DNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Protein-containing Complex Binding	Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-rich Strand Telomeric DNA Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Repair DNA Damage Response Regulation Of DNA Double-strand Break Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination Chromatin Organization DNA Damage Response Telomere Maintenance Via Telomerase Positive Regulation Of Cell Population Proliferation Hemopoiesis Protein Localization To Chromosome Homeostasis Of Number Of Cells Within A Tissue Chromosome Organization Meiotic Cell Cycle Protein Localization To Site Of Double-strand Break
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Menopause (age at onset) ( 26414677) White blood cell count (basophil) ( 27863252 29403010)	Airway imaging phenotypes ( 26030696) Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: POLA1 POLA2 RPA1	70 interacting genes: AICDA AJUBA AKTIP ASCC2 ATM ATR BLM BRCA2 BRIP1 CCNA1 CEBPA CPE CSNK2B DMC1 EHMT2 ERCC1 ERCC4 GNB5 GRB2 HAX1 HELB HGH1 HIRA HNRNPUL1 HSPA6 HUS1 KAT2A KAT2B MCM2 MCM7 MMS22L MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRIMPOL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RECQL RFWD3 RIPK1 RNF20 RNF40 RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SEM1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WAS WRN XPA XPC ZBTB14
Entrez ID		92797	6117
HPRD ID		09979	01565
Ensembl ID		ENSG00000127311	ENSG00000132383
Uniprot IDs		F5H1I4 Q8NG08	P27694
PDB IDs		7XV1	1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N 5EAY 5N85 5N8A 7XUT 7XUV 7XUW 7XV0 7XV1 7XV4 8JZV 8JZY 8K00 8RK2 9J1S 9MJ5
Enriched GO Terms of Interacting Partners?		Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication DNA Replication Initiation Nucleotide-excision Repair DNA-templated DNA Replication DNA Metabolic Process DNA Biosynthetic Process Single-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process Double-strand Break Repair Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Macromolecule Biosynthetic Process Leading Strand Elongation Single-stranded Telomeric DNA Binding Nucleic Acid Metabolic Process DNA Binding G-rich Strand Telomeric DNA Binding DNA Strand Elongation Involved In DNA Replication Chromatin Binding DNA Replication Factor A Complex Lateral Element DNA Polymerase Activity DNA Repair DNA Replication Origin Binding DNA Strand Elongation Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Chromatin-protein Adaptor Activity DNA-directed DNA Polymerase Activity Telomere Maintenance Via Telomerase Protein Localization To Organelle RNA-templated DNA Biosynthetic Process Protein Localization To Site Of Double-strand Break Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Mismatch Repair DNA Damage Response Condensed Chromosome Base-excision Repair Homeostasis Of Number Of Cells Within A Tissue DNA Synthesis Involved In DNA Repair Site Of DNA Damage Condensed Nuclear Chromosome Male Germ Cell Nucleus Double-strand Break Repair Via Nonhomologous End Joining Damaged DNA Binding Nucleoplasm	DNA Metabolic Process DNA Repair DNA Damage Response DNA Recombination Cellular Response To Stress Double-strand Break Repair Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction In Response To DNA Damage Macromolecule Metabolic Process Single-stranded DNA Binding Cellular Response To Radiation Nucleoplasm DNA Replication Nucleotide-excision Repair DNA Damage Checkpoint Signaling Response To Ionizing Radiation Response To Radiation Site Of Double-strand Break Replication Fork Processing Chromosome, Telomeric Region Chromosome Organization Cellular Response To Ionizing Radiation Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Telomere Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Mismatch Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Response To UV Regulation Of Cellular Response To Stress DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding DNA Replication Factor A Complex MutLalpha Complex Binding Response To Gamma Radiation Mitotic Recombination DNA Helicase Activity
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