DNER and RSPH1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DNER	RSPH1
Description		delta/notch like EGF repeat containing	radial spoke head component 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Plasma Membrane Membrane Dendrite Neuronal Cell Body	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3
	Molecular Function	Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Clathrin Binding	Protein Binding
	Biological Process	Neuron Migration Endocytosis Notch Signaling Pathway Notch Receptor Processing Nervous System Development Synapse Assembly Central Nervous System Development Glial Cell Differentiation Skeletal Muscle Fiber Development	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Carotid intima media thickness x smoking interaction ( 32117412) Cerebral amyloid angiopathy in APOEe4 non-carrier Alzheimer’s disease ( 34020725) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29691431) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Type 2 diabetes ( 24101674)
Interacting Genes		3 interacting genes: AP1G1 PDLIM7 RSPH1	125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793
Entrez ID		92737	89765
HPRD ID		09531	11651
Ensembl ID		ENSG00000187957	ENSG00000160188
Uniprot IDs		Q8NFT8	Q8WYR4
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Budding From Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Radial Spoke Head 1 Radial Spoke Head 3 Radial Spoke Head Outer Dense Fiber Golgi To Lysosome Transport Endocytosis Endosome To Melanosome Transport AP-1 Adaptor Complex Radial Spoke Muscle Alpha-actinin Binding Meiotic Spindle Organelle Organization Clathrin Adaptor Activity Import Into Cell Intracellular Vesicle Golgi To Vacuole Transport GTP-dependent Protein Binding Melanosome Assembly Platelet Dense Granule Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Membrane Coat Filamentous Actin 9+2 Motile Cilium Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Vesicle Budding From Membrane Synaptic Vesicle Endocytosis Melanosome Organization Pigment Granule Organization Presynaptic Endocytosis Kinesin Binding Positive Regulation Of Regulated Secretory Pathway Condensed Nuclear Chromosome Regulation Of Natural Killer Cell Mediated Cytotoxicity Axoneme Assembly Cytoskeleton Organization Regulation Of Natural Killer Cell Mediated Immunity Collagen Binding Positive Regulation Of Leukocyte Mediated Cytotoxicity Secretory Granule Organization Positive Regulation Of Cell Killing Clathrin-coated Pit Vesicle-mediated Transport Clathrin-coated Vesicle	Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly
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