DNER

Description		delta/notch like EGF repeat containing
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Plasma Membrane Membrane Dendrite Neuronal Cell Body
	Molecular Function	Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Clathrin Binding
	Biological Process	Neuron Migration Endocytosis Notch Signaling Pathway Notch Receptor Processing Nervous System Development Synapse Assembly Central Nervous System Development Glial Cell Differentiation Skeletal Muscle Fiber Development
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Carotid intima media thickness x smoking interaction ( 32117412) Cerebral amyloid angiopathy in APOEe4 non-carrier Alzheimer’s disease ( 34020725) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29691431) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Type 2 diabetes ( 24101674)
Interacting Genes		3 interacting genes: AP1G1 PDLIM7 RSPH1
Entrez ID		92737
HPRD ID		09531
Ensembl ID		ENSG00000187957
Uniprot IDs		Q8NFT8
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Budding From Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Radial Spoke Head 1 Radial Spoke Head 3 Radial Spoke Head Outer Dense Fiber Golgi To Lysosome Transport Endocytosis Endosome To Melanosome Transport AP-1 Adaptor Complex Radial Spoke Muscle Alpha-actinin Binding Meiotic Spindle Organelle Organization Clathrin Adaptor Activity Import Into Cell Intracellular Vesicle Golgi To Vacuole Transport GTP-dependent Protein Binding Melanosome Assembly Platelet Dense Granule Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Membrane Coat Filamentous Actin 9+2 Motile Cilium Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Vesicle Budding From Membrane Synaptic Vesicle Endocytosis Melanosome Organization Pigment Granule Organization Presynaptic Endocytosis Kinesin Binding Positive Regulation Of Regulated Secretory Pathway Condensed Nuclear Chromosome Regulation Of Natural Killer Cell Mediated Cytotoxicity Axoneme Assembly Cytoskeleton Organization Regulation Of Natural Killer Cell Mediated Immunity Collagen Binding Positive Regulation Of Leukocyte Mediated Cytotoxicity Secretory Granule Organization Positive Regulation Of Cell Killing Clathrin-coated Pit Vesicle-mediated Transport Clathrin-coated Vesicle
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