CYTIP and CYTH3

Number of citations of the paper that reports this interaction (PubMedID 12606567)
43

Data Source:
HPRD (in vitro)

		CYTIP	CYTH3
Description		cytohesin 1 interacting protein	cytohesin 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cell Cortex	Golgi Membrane Ruffle Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding
	Biological Process	Regulation Of Cell Adhesion	Regulation Of ARF Protein Signal Transduction Positive Regulation Of Cell Adhesion Golgi Vesicle Transport Establishment Of Epithelial Cell Polarity
Pathways			Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Inositol-(1,3,4,5,6)-Pentakisphosphate
Diseases
GWAS		Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Asthma ( 27611488) Body mass index ( 26426971) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Shigella-associated diarrhea ( 33649051)
Interacting Genes		9 interacting genes: ARX CYTH1 CYTH2 CYTH3 KIF9 MCRS1 SCNM1 SHANK3 SOCS1	10 interacting genes: ARFIP2 CALCOCO1 CNKSR1 CYTIP FRMD4B IFI35 ITSN1 PIK3CA SNCA TAMALIN
Entrez ID		9595	9265
HPRD ID		09192	05469
Ensembl ID		ENSG00000115165	ENSG00000008256
Uniprot IDs		O60759	B7Z2V9 O43739
PDB IDs		2Z17	4KAX 6U3E 6U3G
Enriched GO Terms of Interacting Partners?		Regulation Of ARF Protein Signal Transduction Bicellular Tight Junction Establishment Of Epithelial Cell Polarity Adherens Junction Guanyl-nucleotide Exchange Factor Activity Regulation Of Small GTPase Mediated Signal Transduction Lipid Binding Anchoring Junction Establishment Of Cell Polarity Guanylate Kinase-associated Protein Clustering Embryonic Olfactory Bulb Interneuron Precursor Migration	Cell Cortex Cytoplasm Macrophage Activation Regulation Of Cellular Respiration Presynaptic Endocytosis Synaptic Vesicle Endocytosis Regulation Of Endocytosis Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
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