CYTIP and ARX

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		CYTIP	ARX
Description		cytohesin 1 interacting protein	aristaless related homeobox
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cell Cortex	Chromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Positive Regulation Of Gene Expression Globus Pallidus Development Olfactory Bulb Development Cerebral Cortex Tangential Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Cell Proliferation In Forebrain Cerebral Cortex GABAergic Interneuron Migration Cell Differentiation Forebrain Development Organ Growth Lipid Digestion Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Neuron Fate Commitment Neuron Development Regulation Of Epithelial Cell Proliferation Epithelial Cell Fate Commitment Interneuron Migration
Pathways
Drugs
Diseases			Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Early infantile epileptic encephalopathy; Ohtahara syndrome Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: ARX CYTH1 CYTH2 CYTH3 KIF9 MCRS1 SCNM1 SHANK3 SOCS1	8 interacting genes: ACTN2 CYTIP DNM2 IPO13 NELL2 PKM SETD2 TLE5
Entrez ID		9595	170302
HPRD ID		09192	02307
Ensembl ID		ENSG00000115165	ENSG00000004848
Uniprot IDs		O60759	Q96QS3
PDB IDs		2Z17
Enriched GO Terms of Interacting Partners?		Regulation Of ARF Protein Signal Transduction Bicellular Tight Junction Establishment Of Epithelial Cell Polarity Adherens Junction Guanyl-nucleotide Exchange Factor Activity Regulation Of Small GTPase Mediated Signal Transduction Lipid Binding Anchoring Junction Establishment Of Cell Polarity Guanylate Kinase-associated Protein Clustering Embryonic Olfactory Bulb Interneuron Precursor Migration
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