PSMF1 and RALYL

Number of citations of the paper that reports this interaction (PubMedID 19447967)
24

Data Source:
BioGRID (two hybrid)

		PSMF1	RALYL
Description		proteasome inhibitor subunit 1	RALY RNA binding protein like
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Cytoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Proteasome Binding	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Proteasome assembly
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Neonatal white matter microstructure ( 33009551)	Adult body size ( 32376654) Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Systolic blood pressure ( 27841878) Trunk fat mass ( 28552196)
Interacting Genes		35 interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2	25 interacting genes: ADISSP AEBP2 AEN BYSL CAMK2A CCDC85B CEP170P1 EWSR1 EXOSC7 FXR1 FXR2 HNRNPC LMO3 LRRK2 MBD2 MCRS1 NXF1 PCBP2 PSMF1 RBM41 THAP1 TIGD3 TSC1 TSNAX ZNF408
Entrez ID		9491	138046
HPRD ID		17919	11236
Ensembl ID		ENSG00000125818	ENSG00000184672
Uniprot IDs		A0A140VJT2 B4DXW9 Q5QPM7 Q92530	B3KT61 Q86SE5
PDB IDs		2VT8 4OUH
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Processing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus RNA Processing Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Neuron Projection Arborization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process RNA Metabolic Process MRNA Stabilization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Neuron Projection Arborization Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process SH3 Domain Binding Nucleic Acid Metabolic Process Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process TORC2 Complex Disassembly Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Pro-B Cell Differentiation	Nucleic Acid Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus RNA Binding MRNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Nucleolus Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Translation Regulator Activity Cytoplasmic Stress Granule Nucleoplasm Regulation Of RNA Metabolic Process Protein Homodimerization Activity Poly(U) RNA Binding Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening MRNA 3'-UTR AU-rich Region Binding MRNA Transport Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Hydrolase Activity Peptidyl-threonine Autophosphorylation Neuron Projection Negative Regulation Of Telomere Maintenance Memory T Cell Differentiation Negative Regulation Of Macroautophagy RNA Transport Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleosomal DNA Binding Presynaptic Modulation Of Chemical Synaptic Transmission Nucleolus Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of MRNA Stability U12 SnRNA Binding
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