PSMF1

Gene Name		proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Negative Regulation Of Endopeptidase Activity Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-protein Interactions		23 interactors: BEND7 CCDC85B CD2BP2 CTBP2 DVL3 FBXO7 HOOK2 KHDRBS3 LDOC1 MAGEA11 MIEF2 NUDT21 PAK7 PDLIM7 PSMA7 QKI RALYL RBFOX1 RBFOX2 RBMX RHOXF2 RNF126 TRAF2
Entrez ID		9491
HPRD ID		17919
Ensembl ID		ENSG00000125818
Uniprot IDs		E7ER20 F5H4Z3 Q5QPM7 Q92530
PDB IDs		2VT8
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of RNA Splicing Gene Expression Regulation Of Cellular Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein K63-linked Ubiquitination Protein Polyubiquitination RNA Metabolic Process Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Cellular Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of MRNA Splicing, Via Spliceosome Protein Catabolic Process Positive Regulation Of JUN Kinase Activity 3'-UTR-mediated MRNA Destabilization Regulation Of Metabolic Process Neuromuscular Process Controlling Balance Regulation Of JUN Kinase Activity Regulation Of MRNA Processing Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of Chromatin Binding Non-canonical Wnt Signaling Pathway Via MAPK Cascade Protein Oligomerization Neuromuscular Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition MRNA Destabilization Negative Regulation Of Glial Cell Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade RNA Transport Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process
Tagcloud ?		affymetrix alanine alt aminotransferase annotation aspartate assayed ast cideb cnv cnvs copy dffa helixtree kare1 kare2 koreans netbox overlapped programmed psma3 psmc5 psmc6 psmd12 sdc4 siah1 traits unrelated wide