PSMF1 and QKI

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSMF1	QKI
Description		proteasome inhibitor subunit 1	QKI, KH domain containing RNA binding
Image
GO Annotations	Cellular Component	Proteasome Complex Cytoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Synapse
	Molecular Function	Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Proteasome Binding	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding SH3 Domain Binding MiRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process	Vasculogenesis MRNA Processing Regulation Of Translation Spermatid Development Intracellular MRNA Localization Axon Ensheathment RNA Splicing Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Microglia Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Myelination Negative Regulation Of Type I Interferon Production Stress Granule Assembly Vascular Associated Smooth Muscle Cell Differentiation Myelination Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation MRNA Transport Regulation Of Cell Development Negative Regulation Of Cold-induced Thermogenesis Spliceosome-depend Formation Of Circular RNA Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Myofibroblast Contraction Regulation Of Multicellular Organismal Development Negative Regulation Of MiRNA Catabolic Process
Pathways		Proteasome assembly	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Neonatal white matter microstructure ( 33009551)	Cataracts ( 34127677) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Fasting insulin ( 34059833) Height ( 31562340) Hemoglobin ( 32888494) Incident myocardial infarction ( 26950853) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Platelet distribution width ( 32888494) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to TNF antagonist treatment ( 18615156) Seasonality and depression ( 30217971) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 30718926)
Interacting Genes		35 interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2	90 interacting genes: ALG13 ANKHD1 APP ATXN1 BAG4 BCAS2 CALD1 CARM1 CCDC59 CCND3 CDKN2D CEBPA CPSF7 DAZ1 DAZ4 DEPP1 DMRTB1 EIF4ENIF1 FBXO7 FHL3 FUBP3 HCLS1 HLCS HNRNPH2 HNRNPK HNRNPLL IL7R KIF21B LSM3 LSM5 MBNL1 MBNL2 MIR141 MIR19B2 MIR200A MIR34B MIR34C MIR7-1 MRPL44 MSI2 NABP1 NEIL3 NIP7 NXF1 PCBP1 PCBP2 PCBP3 PCBP4 PCGF5 PIAS1 PRKAB2 PRMT1 PRPF39 PRPF6 PRRC2B PSMF1 PTBP1 PTBP2 RALY RBFOX1 RBFOX2 RBM11 RBM14 RBM23 RBM42 RBM7 RBPMS RNF138 RPL9 SECISBP2 SERF2 SLAIN1 SNRPA SNRPC TEX11 THAP1 TIAL1 TNRC6A TRNAU1AP TSG101 TXNL4A U2AF2 UNKL USH1C UTP6 WDR77 YTHDF1 YTHDF3 ZC3H10 ZMAT5
Entrez ID		9491	9444
HPRD ID		17919	06691
Ensembl ID		ENSG00000125818	ENSG00000112531
Uniprot IDs		A0A140VJT2 B4DXW9 Q5QPM7 Q92530	Q8WY44 Q96PU8
PDB IDs		2VT8 4OUH	4JVH
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Processing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus RNA Processing Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Neuron Projection Arborization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process RNA Metabolic Process MRNA Stabilization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Neuron Projection Arborization Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process SH3 Domain Binding Nucleic Acid Metabolic Process Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process TORC2 Complex Disassembly Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Pro-B Cell Differentiation	RNA Binding Nucleic Acid Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Processing RNA Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleoplasm Negative Regulation Of RNA Splicing Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA 3'-UTR Binding Cytoplasmic Stress Granule Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Commitment Complex Regulation Of Translation Viral RNA Genome Replication Regulation Of MRNA Stability Negative Regulation Of RNA Metabolic Process
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