RNF122 and UBE2L6

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		RNF122	UBE2L6
Gene Name		ring finger protein 122	ubiquitin-conjugating enzyme E2L 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane	Cytosol
	Molecular Function	Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity ISG15 Transferase Activity
	Biological Process		Cellular Protein Modification Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antiviral mechanism by IFN-stimulated genes Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L6 UBE2N	37 interactors: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 LONRF1 MAP3K1 MUL1 PARK2 PJA2 RAD23A RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM8 UBA6 UBA7 UBC UBE3A
Entrez ID		79845	9246
HPRD ID		11498	04867
Ensembl ID		ENSG00000133874	ENSG00000156587
Uniprot IDs		Q9H9V4	O14933
PDB IDs			1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Innate Immune Response Proteolysis Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity ISG15-protein Conjugation Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Immune Response-regulating Signaling Pathway Immune Response Defense Response Positive Regulation Of Protein Ubiquitination Cellular Protein Modification Process Positive Regulation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Cellular Response To Organic Substance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint Immune System Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Proteolysis Protein Polyubiquitination Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Metabolic Process Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Protein Monoubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Cytokine Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Viral Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Negative Regulation Of Viral Release From Host Cell Cellular Response To Stimulus Regulation Of Viral Release From Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Apoptotic Process Response To Stimulus Programmed Cell Death Regulation Of Cytokine Production Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Cell Death Regulation Of Kinase Activity Death Cellular Response To Cytokine Stimulus
Tagcloud ?			btbr c57blks db dba diabesity dissection hlbomdife hllt hyperglycaemia ifi202b inbred introgression jngj lean lep lepr lisch nzo ob obesity outcross pctp positional sorcs1 tallyho tbc1d1 tomosyn zealand zfp69
Tagcloud (Difference) ?			btbr c57blks db dba diabesity dissection hlbomdife hllt hyperglycaemia ifi202b inbred introgression jngj lean lep lepr lisch nzo ob obesity outcross pctp positional sorcs1 tallyho tbc1d1 tomosyn zealand zfp69
Tagcloud (Intersection) ?