RNF122 and CTSA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF122	CTSA
Description		ring finger protein 122	cathepsin A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Membrane	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Lumenal Side Of Lysosomal Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Proteolysis Intracellular Protein Transport Regulation Of Protein Stability Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy
Pathways			MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism
Drugs
Diseases			Galactosialidosis
GWAS		Pulse pressure ( 30578418)
Interacting Genes		12 interacting genes: AQP1 CDS2 CTSA GPR37L1 PLLP RIGI UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L6 UBE2N	46 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC10A6 SLC18A1 SLC30A2 SLC71A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2
Entrez ID		79845	5476
HPRD ID		11498	02020
Ensembl ID		ENSG00000133874	ENSG00000064601
Uniprot IDs		Q9H9V4	B4E324 P10619 X6R5C5 X6R8A1
PDB IDs			1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation ISG15 Transferase Activity Proteolysis Protein Monoubiquitination ISG15-protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Transferase Activity Positive Regulation Of Protein Polyubiquitination ATP Binding Regulation Of Protein Polyubiquitination Protein Modification Process Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Nucleotide Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Catabolic Process Protein Autoubiquitination Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Lumenal Side Of Lysosomal Membrane Antiviral Innate Immune Response Phosphatidate Cytidylyltransferase Activity Prosaposin Receptor Activity Regulation Of Transcytosis Protein Metabolic Process TOR Signaling Ubiquitin Protein Ligase Activity Negative Regulation Of TOR Signaling Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of TORC1 Signaling UBC13-MMS2 Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Lumen Acetylcholine Receptor Regulator Activity Renal Water Transport Ganglioside Catabolic Process
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