TRPC4AP and EDEM2

		TRPC4AP	EDEM2
Description		transient receptor potential cation channel subfamily C member 4 associated protein	ER degradation enhancing alpha-mannosidase like protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Calcium Channel Activity Protein Binding Phosphatase Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Hair Follicle Maturation Calcium Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Carbohydrate Metabolic Process Response To Unfolded Protein Glycoprotein Metabolic Process Viral Protein Processing Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Ubiquitin-dependent Glycoprotein ERAD Pathway Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		TRP channels	ER Quality Control Compartment (ERQC) Maturation of spike protein
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Prothrombin time ( 22703881) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 30275531) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Offspring birth weight ( 31043758) Protein C levels ( 28082259 20802025) Prothrombin time ( 22703881) QRS complex (Cornell) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Venous thromboembolism ( 31676865) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: CHMP4C CHUK IKBKB IKBKG MTDH RIPK1 TAB1 TNFRSF1A TRADD TRAF2	1 interacting genes: RPS3A
Entrez ID		26133	55741
HPRD ID		09238	09841
Ensembl ID		ENSG00000100991	ENSG00000088298
Uniprot IDs		B4DW48 Q8TEL6	Q9BV94
PDB IDs
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Transferrin Receptor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor IkappaB Kinase Activity Death Domain Binding Positive Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Tumor Necrosis Factor Binding Death-inducing Signaling Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Receptor Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Defense Response Inflammatory Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Establishment Of Endothelial Barrier Regulation Of Signal Transduction Defense Response Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Immune System Process Protein Heterodimerization Activity Innate Immune Response	Cul4A-RING E3 Ubiquitin Ligase Complex Hair Follicle Maturation Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
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