SERP1 and SEC61A1

Number of citations of the paper that reports this interaction (PMID 10601334)
18

Data Source:
HPRD (in vivo)

		SERP1	SEC61A1
Gene Name		stress-associated endoplasmic reticulum protein 1	Sec61 alpha 1 subunit (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ribosome Cytoplasmic Microtubule Integral Component Of Membrane	Rough Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function		Protein Binding Ribosome Binding
	Biological Process	Skeletal System Development Glucose Metabolic Process Cellular Protein Modification Process Protein Glycosylation Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Plasma Membrane Organization Post-embryonic Development Multicellular Organismal Aging Protein Transport Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion Cellular Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent SRP-dependent Cotranslational Protein Targeting To Membrane Posttranslational Protein Targeting To Membrane Endoplasmic Reticulum Organization Cell Growth Response To Interferon-gamma Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Targeting To ER
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Translation SRP-dependent cotranslational protein targeting to membrane Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP CANX SCNN1A SCNN1G SEC61A1 SEC61B TMEM79	6 interactors: ASNA1 BAG6 CALM1 HSPA5 MLH1 SERP1
Entrez ID		27230	29927
HPRD ID		18037	15316
Ensembl ID		ENSG00000120742	ENSG00000058262
Uniprot IDs		Q9Y6X1	B3KME8 B3KNF6 P61619
PDB IDs
Enriched GO Terms of Interacting Partners?		Multicellular Organismal Water Homeostasis Water Homeostasis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Body Fluid Levels Transport Sodium Ion Homeostasis Antigen Processing And Presentation Of Peptide Antigen Chemical Homeostasis Antigen Processing And Presentation Excretion Establishment Of Localization In Cell Sensory Perception Of Taste Cellular Localization Metal Ion Homeostasis Secretion By Cell SRP-dependent Cotranslational Protein Targeting To Membrane Homeostatic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Ion Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Localization To Endoplasmic Reticulum Synaptic Growth At Neuromuscular Junction Secretion Cell Maturation Cell Growth Collateral Sprouting In Absence Of Injury Cuticle Development Protein Targeting To Membrane Cornification Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol Sodium Ion Transmembrane Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Immune System Process Axon Choice Point Recognition Establishment Of Protein Localization To Membrane Posttranslational Protein Targeting To Membrane Sodium Ion Transport Neuron Remodeling Neurological System Process Exocytosis Establishment Of Protein Localization To Organelle Protein Localization To Membrane Establishment Of Skin Barrier Cellular Copper Ion Homeostasis Regulation Of Water Loss Via Skin	Protein Insertion Into ER Membrane Response To Endoplasmic Reticulum Stress Protein Insertion Into Membrane Membrane Organization Substantia Nigra Development Endoplasmic Reticulum Organization Cellular Localization Synapsis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Homologous Chromosome Segregation Positive Regulation Of Nuclease Activity Endomembrane System Organization Platelet Degranulation Positive Regulation Of Protein Kinase Activity Meiotic Chromosome Segregation Positive Regulation Of Kinase Activity Protein Localization To Organelle Midbrain Development Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Transferase Activity Meiotic Spindle Midzone Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Meiotic Metaphase I Plate Congression Cellular Response To Unfolded Protein Meiosis I ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Stress Catabolic Process Cell Activation Response To Unfolded Protein Negative Regulation Of Mitotic Recombination Cerebellum Structural Organization Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Regulation Of Protein Kinase Activity Protein Localization Regulation Of Cellular Protein Metabolic Process Brain Development Regulation Of Kinase Activity Meiotic Nuclear Division Head Development Cellular Macromolecule Catabolic Process System Development Positive Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process
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