SERP1 and GKN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SERP1	GKN1
Description		stress associated endoplasmic reticulum protein 1	gastrokine 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Membrane	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Endomembrane System Secretory Granule
	Molecular Function	Protein Binding	Protein Binding Growth Factor Activity
	Biological Process	Skeletal System Development Glucose Metabolic Process Protein Glycosylation Response To Unfolded Protein Plasma Membrane Organization Post-embryonic Development Protein Transport Insulin Secretion Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion	Signal Transduction Digestion Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division
Pathways		XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131)
Interacting Genes		56 interacting genes: ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FKBP7 FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A1 SLC10A6 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SLC71A2 SSMEM1 STX1A STX2 STX4 TIMMDC1 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9	12 interacting genes: AQP6 CDC27 FAM209A MFF PLPP6 SERP1 SERP2 SMCO4 TMEM179B TREX1 UBE2J1 VAPA
Entrez ID		27230	56287
HPRD ID		18037	16217
Ensembl ID		ENSG00000120742	ENSG00000169605
Uniprot IDs		Q9Y6X1	A0A8I5KHR1 Q53YU7 Q9NS71
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Norepinephrine Uptake Endoplasmic Reticulum Serotonin Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Amine Transport Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Protein Binding Neurotransmitter Transport Apical Plasma Membrane Mitochondrial Membrane Endoplasmic Reticulum Membrane Putrescine Transmembrane Transporter Activity Monoatomic Ion Transport Neurotransmitter Reuptake Dopamine Transport Sensory Perception Of Salty Taste Xenobiotic Transmembrane Transporter Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Bile Acid:sodium Symporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Neurotransmitter Uptake Lumenal Side Of Endoplasmic Reticulum Membrane Basolateral Plasma Membrane External Side Of Plasma Membrane Cornified Envelope Assembly Monoatomic Cation Transport Xenobiotic Transport Across Blood-brain Barrier Sec61 Translocon Complex Import Into Cell Organic Cation Transport Organic Hydroxy Compound Transport Cellular Response To Aldosterone Sodium Channel Complex Toxin Transmembrane Transporter Activity	Endoplasmic Reticulum Membrane Nitrate Transmembrane Transporter Activity Membrane Azurophil Granule Membrane Endoplasmic Reticulum Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Response To Endoplasmic Reticulum Stress Nuclear Inner Membrane Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Cellular Response To Type I Interferon DNA Exonuclease Activity Retrotransposition Transposition Endoplasmic Reticulum Unfolded Protein Response Response To Unfolded Protein FFAT Motif Binding DNA Synthesis Involved In UV-damage Excision Repair Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation
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