NAF1 and MED31

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAF1	MED31
Description		nuclear assembly factor 1 ribonucleoprotein	mediator complex subunit 31
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Ribonucleoprotein Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding Telomerase RNA Binding	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	SnoRNA Guided RRNA Pseudouridine Synthesis Box H/ACA SnoRNP Assembly Pseudouridine Synthesis RRNA Processing Protein-RNA Complex Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Ribosome Biogenesis RNA Stabilization Telomerase RNA Stabilization Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Holoenzyme Complex Assembly	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Limb Development Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Chronotype ( 30696823) Colorectal cancer ( 25023989) Daytime nap ( 33568662) Hair morphology ( 19896111) Leukocyte telomere length ( 31171785 32109421) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) TPE interval (recovery after exercise) ( 32386560)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		26 interacting genes: BOLL CSNK2A1 DAB1 ELOA FAM168A HERPUD2 KRTAP19-3 KRTAP19-7 KRTAP6-1 KRTAP6-2 MAGED1 MED31 MSX2 RAMAC RBFOX2 SCARNA13 SCARNA8 SH3RF1 SNORA74A SNX33 SORBS3 SS18L1 TENT5B TLE5 UBE2I YWHAE	58 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1
Entrez ID		92345	51003
HPRD ID		10054	14382
Ensembl ID		ENSG00000145414	ENSG00000108590
Uniprot IDs		Q96HR8	Q9Y3C7
PDB IDs		2EQN	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?			Nucleus Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Identical Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Nucleoplasm
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