DNAJA1 and HMGCL

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		DNAJA1	HMGCL
Name		DnaJ heat shock protein family (Hsp40) member A1	3-hydroxy-3-methylglutaryl-CoA lyase
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Tat Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding	Magnesium Ion Binding Catalytic Activity Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Lyase Activity Oxo-acid-lyase Activity Manganese Ion Binding Metal Ion Binding
	Biological Process	Protein Folding Response To Unfolded Protein Response To Heat Negative Regulation Of Protein Ubiquitination Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	L-leucine Catabolic Process Lipid Metabolic Process Mitochondrion Organization Ketone Body Biosynthetic Process
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Mitochondrial unfolded protein response (UPRmt)	Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs		None	3-hydroxyglutaric acid
Diseases		None	3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		No GWAS studies recorded	High light scatter reticulocyte count ( 27863252 ) Immature fraction of reticulocytes ( 27863252 ) Red blood cell count ( 32888494 ) Reticulocyte fraction of red cells ( 27863252 )
Novel Interactors		None recorded	1 novel interactors: SMARCA4
Interacting Genes		30 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR CRBN DSCR9 ERG FZR1 HIVEP1 HMGCL HSPA8 HUNK LINC01554 LSM2 NELFCD NUDT3 OGT PAXIP1 PGR PTEN PTTG1 SNCA SUMO2 SUMO4 TM4SF1 TXN UBC	12 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 IKBKB MS4A7 NEDD4 PEX5 RNF126 UBC
Entrez ID		3301	3155
HPRD ID		04159	02003
Ensembl ID		ENSG00000086061	ENSG00000117305
Uniprot IDs		B7Z5C0 P31689	P35914
PDB IDs		2LO1 2M6Y 6E8M 8E2O	2CW6 3MP3 3MP4 3MP5
GO Terms Enriched among Interactors		Protein Tag Activity Nucleus Enzyme Binding Negative Regulation Of Protein-containing Complex Assembly Anaphase-promoting Complex Binding Protein Modification By Small Protein Conjugation Ubiquitin Ligase Activator Activity	Protein Monoubiquitination Tat Protein Binding Positive Regulation Of DNA Binding Cerebral Cortex Neuron Differentiation Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Modification Process Transcriptional Start Site Selection At RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Forebrain Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle, Embryonic Trochlear Nerve Development Post-translational Protein Modification Protein Targeting Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Fatty Acid Beta-oxidation Transcription Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding Germinal Vesicle Protein-containing Complex Organization Protein-containing Complex Assembly RNA Polymerase II Core Complex Assembly Protein Metabolic Process Lipid Oxidation 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Fatty Acid Catabolic Process Mitochondrial Ribonuclease P Complex Fatty Acid Oxidation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Mitochondrial RNA 5'-end Processing Protein Tetramerization Protein-folding Chaperone Binding Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Blood Vessel Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation