DNAJA1 and LSM2

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
HPRD (two hybrid)

		DNAJA1	LSM2
Description		DnaJ heat shock protein family (Hsp40) member A1	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Tat Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding	RNA Binding Protein Binding U6 SnRNA Binding Small GTPase Binding
	Biological Process	Protein Folding Response To Unfolded Protein Response To Heat Negative Regulation Of Protein Ubiquitination Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing MRNA Catabolic Process RNA Splicing
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Mitochondrial unfolded protein response (UPRmt)	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)
Interacting Genes		30 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR CRBN DSCR9 ERG FZR1 HIVEP1 HMGCL HSPA8 HUNK LINC01554 LSM2 NELFCD NUDT3 OGT PAXIP1 PGR PTEN PTTG1 SNCA SUMO2 SUMO4 TM4SF1 TXN UBC	39 interacting genes: BANP CBX8 CEBPA CRMP1 DNAAF11 DNAJA1 ERG28 EXOSC10 GBP2 KRT13 LGALS7 LGALS7B LNX1 LSM1 LSM12 LSM3 LSM5 LSM6 LSM7 LSM8 LZTS1 MAGEA3 MAGEA6 MEOX2 PATL1 PCM1 PNMA1 RALA REL RSRC1 SF3B2 SMN1 SNRPD2 SNRPE TEX11 TLE5 TRIM54 ZBTB16 ZNF408
Entrez ID		3301	57819
HPRD ID		04159	06282
Ensembl ID		ENSG00000086061	ENSG00000204392
Uniprot IDs		B7Z5C0 P31689	Q9Y333
PDB IDs		2LO1 2M6Y 6E8M 8E2O	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Nucleus Enzyme Binding Negative Regulation Of Protein-containing Complex Assembly Anaphase-promoting Complex Binding Protein Modification By Small Protein Conjugation Ubiquitin Ligase Activator Activity	U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Lsm2-8 Complex U4/U6 X U5 Tri-snRNP Complex U6 SnRNP Lsm1-7-Pat1 Complex RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome Precatalytic Spliceosome MRNA Processing Spliceosomal Complex RNA Processing U12-type Spliceosomal Complex MRNA Catabolic Process RNA Metabolic Process Catalytic Step 2 Spliceosome Ribonucleoprotein Complex RNA Binding Spliceosomal Complex Assembly RNA Catabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process P-body PICln-Sm Protein Complex Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Spliceosomal SnRNP Assembly 7-methylguanosine Cap Hypermethylation U4 SnRNP Methylosome Nuclear Speck Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA U6 SnRNA Binding Histone MRNA Catabolic Process P-body Assembly Negative Regulation Of Metabolic Process MRNA Methylguanosine-cap Decapping Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression U1 SnRNP U5 SnRNP RNA Decapping Protein Binding
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