DNAJA1 and CD58

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		DNAJA1	CD58
Name		DnaJ heat shock protein family (Hsp40) member A1	CD58 molecule
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Tat Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Response To Heat Negative Regulation Of Protein Ubiquitination Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	Immune Response Positive Regulation Of Interleukin-8 Production Heterotypic Cell-cell Adhesion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Mitochondrial unfolded protein response (UPRmt)	Cell surface interactions at the vascular wall Neutrophil degranulation
GWAS		No GWAS studies recorded	Multiple sclerosis ( 19525953 19525955 21244703 21833088 22190364 24076602 27386562 31604244 ) Primary biliary cholangitis ( 28425483 ) Systemic lupus erythematosus ( 33272962 33536424 )
Interacting Genes		30 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR CRBN DSCR9 ERG FZR1 HIVEP1 HMGCL HSPA8 HUNK LINC01554 LSM2 NELFCD NUDT3 OGT PAXIP1 PGR PTEN PTTG1 SNCA SUMO2 SUMO4 TM4SF1 TXN UBC	4 interacting genes: APP CD2 DNAJA1 HERPUD1
Entrez ID		3301	965
HPRD ID		04159	01081
Ensembl ID		ENSG00000086061	ENSG00000116815
Uniprot IDs		B7Z5C0 P31689	P19256
PDB IDs		2LO1 2M6Y 6E8M 8E2O	1CCZ 1CI5 1QA9
GO Terms Enriched among Interactors		Protein Tag Activity Nucleus Enzyme Binding Negative Regulation Of Protein-containing Complex Assembly Anaphase-promoting Complex Binding Protein Modification By Small Protein Conjugation Ubiquitin Ligase Activator Activity	Regulation Of Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Protein-folding Chaperone Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Type II Interferon Production Regulation Of Cellular Response To Stress Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Unfolded Protein Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Membrane Raft Polarization Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Core Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Response To Stress Positive Regulation Of Amyloid Fibril Formation