DNAJA1 and HIVEP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DNAJA1	HIVEP1
Description		DnaJ heat shock protein family (Hsp40) member A1	HIVEP zinc finger 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Tat Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Folding Response To Unfolded Protein Response To Heat Negative Regulation Of Protein Ubiquitination Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS			Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 22488850) Asthma ( 32296059) Body mass index ( 25673413 28892062 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Takayasu arteritis ( 25604533)
Interacting Genes		30 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR CRBN DSCR9 ERG FZR1 HIVEP1 HMGCL HSPA8 HUNK LINC01554 LSM2 NELFCD NUDT3 OGT PAXIP1 PGR PTEN PTTG1 SNCA SUMO2 SUMO4 TM4SF1 TXN UBC	72 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BANP BHLHE40 BNIP3 BRCA1 CACNA1A CCNK CDC37 CLK1 CREB1 CREBBP DNAJA1 ELOA EMG1 FXR1 FXR2 GAA GSDMB HPD HSPA1A IGFN1 IMMT KDF1 MAGED1 MAPK14 MAPK8 MIEN1 MTMR3 NINJ1 NLGN3 NRF1 NUCB1 OGT OTX1 PLEKHB2 POGZ POU2F1 POU6F2 PRKAR1A PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAB1A RBM47 RBPMS RIDA RNF186 ROR2 SDCBP SERTAD1 SH3KBP1 SMAD3 SNX4 SOCS3 SOX10 SP4 SRPK2 STAT3 TENT5B TMEM176A VCF2 VEZF1 ZC3H10 ZFHX3
Entrez ID		3301	3096
HPRD ID		04159	01925
Ensembl ID		ENSG00000086061	ENSG00000095951
Uniprot IDs		B7Z5C0 P31689	A0A0D9SFF3 A0AAQ5BHS1 H7BYU7 P15822
PDB IDs		2LO1 2M6Y 6E8M 8E2O	1BBO 3ZNF 4ZNF
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Nucleus Enzyme Binding Negative Regulation Of Protein-containing Complex Assembly Anaphase-promoting Complex Binding Protein Modification By Small Protein Conjugation Ubiquitin Ligase Activator Activity	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Stability Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Chromatin Regulation Of Developmental Process Regulation Of Biological Quality Transcription By RNA Polymerase II Pyroptotic Inflammatory Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Enzyme Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Regulation Of Multicellular Organismal Process Rhythmic Process DNA-binding Transcription Factor Activity POZ Domain Binding Regulation Of Circadian Rhythm Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Splicing MRF Binding C3HC4-type RING Finger Domain Binding Regulation Of MiRNA-mediated Gene Silencing
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