NOLC1 and POLR1A

Number of citations of the paper that reports this interaction (PubMedID 10567578)
68

Data Source:
HPRD (in vitro, in vivo)

		NOLC1	POLR1A
Description		nucleolar and coiled-body phosphoprotein 1	RNA polymerase I subunit A
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body	DNA-directed RNA Polymerase Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Molecular Function Inhibitor Activity	Magnesium Ion Binding DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding
	Biological Process	Mitotic Cell Cycle RRNA Processing Regulation Of Translation Nucleolus Organization Neural Crest Formation Neural Crest Cell Development	DNA-templated Transcription Transcription By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I Negative Regulation Of Protein Localization To Nucleolus
Pathways			NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs		Doxorubicin
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Smoking initiation ( 33082346) Triglyceride levels ( 32203549)	Facial emotion recognition (sad faces) ( 28608620)
Interacting Genes		19 interacting genes: APP CEBPA CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B ING4 KBTBD8 MDM2 OGT POLR1A PRKACA SRPK2 USP4 YWHAG YWHAQ	10 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN RRN3 SKP2 TCF4
Entrez ID		9221	25885
HPRD ID		03864	10161
Ensembl ID		ENSG00000166197	ENSG00000068654
Uniprot IDs		B2RAU8 Q14978 Q96J17	O95602
PDB IDs			7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Nucleus Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Chromatin Binding TORC1 Signaling Intracellular Signal Transduction C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process TOR Signaling Regulation Of Primary Metabolic Process CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Assembly Regulation Of TORC1 Signaling Regulation Of Translation Regulation Of Translational Initiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Cellular Response To Nutrient Levels Negative Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Protein-containing Complex Organization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Response To Nutrient Levels RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Component Assembly Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Translational Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TOR Signaling Regulation Of Glycolytic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression	Protein-DNA Complex Assembly Nucleolus Organization Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase Binding Molecular Function Inhibitor Activity Nucleolus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Transcription Preinitiation Complex Assembly RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Macromolecule Metabolic Process Roof Of Mouth Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Adaptive Immune Memory Response DNA-templated Transcription Initiation Nucleus Organization Beta-catenin Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Beta-catenin-TCF7L2 Complex RNA Polymerase I Core Binding Positive Regulation Of Metabolic Process
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